several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. this study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-t (hs-tnt) and creatine kinase-mb (ck-mb), in patients with st-segment elevation myocardial infarction (stemi) undergoin...

AIMS Although hirudin is superior to unfractionated heparin for prevention of death, myocardial infarction, or refractory ischaemia in patients with non-ST-elevation acute coronary syndrome, it is not clear whether hirudin is also of benefit in acute coronary syndrome patients undergoing early percutaneous coronary intervention. METHODS AND RESULTS In the OASIS 2 trial, 10 141 patients with n...

BACKGROUND The COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trial was designed to compare optimal medical therapy alone versus optimal medical therapy and percutaneous coronary intervention (PCI) for treatment of patients with stable coronary artery disease and showed equal efficacy for optimal medical therapy with or without PCI. The impact of results ...

More than 4 years have elapsed since the publication of the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial,1 which led to rampant speculation regarding its potential impact on clinical practice. As memories of the heated rhetoric that punctuated that debate fade, we are now in a position to look back with calmer heads and use observational data to s...

Papillary muscle rupture may occur even in patients with small or no myocardial ischemic lesion, and it also arise from iatrogenic complications. We report a case of papillary following artery dissection, that apparently occurred due to catheter intervention. An 83-year-old woman stable angina pectoris underwent percutaneous coronary Coronary dissection during the procedure; however, she showed...

Background: This study aims to evaluate the effect of exercise training on heart rate variability (HRV) and to determine the correlation between parameters of HRV and the ejection fraction in patients with heart failure after percutaneous coronary intervention.Material and Methods: Fifty patients with left ventricular ejection fraction ≤ 40% undergone percutaneous coronary intervention were r...

background: combination antiplatelet therapy is a classic treatment for percutaneous coronary intervention (pci) but this therapy increases gastrointestinal bleeding (gib). this study highlights the incidence of related risk factors of gib and endoscopic findings in patients with gib after pci and combination antiplatelet therapy. materials and methods: a standard check list was used to evaluat...