Friedreich's ataxia (GAA)n repeats of various lengths were cloned into a Saccharymyces cerevisiae plasmid, and their effects on DNA replication were analyzed using two-dimensional electrophoresis of replication intermediates. We found that premutation- and disease-size repeats stalled the replication fork progression in vivo, while normal-size repeats did not affect replication. Remarkably, the...

An examination of fertility trends in countries with multiple DHS surveys found that in the 1990s fertility stalled in mid-transition in seven countries: Bangladesh, Colombia, Dominican Republic, Ghana, Kenya, Peru, and Turkey. In each of these countries fertility was high (>6 births per woman) in the 1950s and then declined to fewer than 5 births per woman in the early or mid-1990s, before sta...

An examination of fertility trends in countries with multiple DHS surveys found that in the 1990s fertility stalled in midtransition in seven countries: Bangladesh, Colombia, Dominican Republic, Ghana, Kenya, Peru, and Turkey. In each of these countries fertility was high (more than six births per woman) in the 1950s and declined to fewer than five births per woman in the early or mid-1990s, be...

The ribosome is able to monitor the structure of the nascent peptide and can stall in response to specific peptide sequences. Such programmed stalling is used for the regulation of gene expression. The molecular mechanisms of the nascent-peptide recognition and ribosome stalling are unknown. We identified the conserved and posttranscriptionally modified 23S rRNA nucleotide m(2)A2503 located at ...

BACKGROUND Most of the recent literature on fertility stalls has concentrated on sub-Saharan Africa and has highlighted flaws in DHS data. No similar detailed research exists for presumed stalls occurring in countries outside that region. This is particularly surprising when considering that cases of fertility stalls have also been suggested in Middle Eastern countries, including Egypt, Syria a...

In this short paper we briefly describe the results of analyzing a large-scale data set of actual YouTube stall patterns collected world-wide as part of Columbia University’s YouSlow project, and how we used it to create a simple model for generating realistic stalling patterns with a given number of stalls, a given average stall duration, and a pattern structure (describing the relative length...