نتایج جستجو برای: starting dose
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The starting dose of FK 506 has been kept the same in the pediatric population as when the drug was introduced: 0.15 mglkgld IV as a continuous infusion and 0.15 mglkg bid orally. 1 The dose was increased in case of rejection if the trough serum FK 506 level was <2 ng/mL and there was no nephrotoxicity. The dose was decreased in the absence of rejection if the serum FK 506 level was > 3 ng/mL o...
Rodent and nonrodent toxicology studies are currently expected to support Phase I trials of antineoplastic drugs in the United States. To determine the predictive value of these studies, we initiated a project to compare preclinical and clinical toxicity data within various drug classes. The first class analyzed was the platinum anticancer drugs. Twelve platinum analogues that had both preclini...
Effect of propylthiouracil (PTU)-induced hypothyroidism during the prepubertal period, at a dose of oneg per kg of the diet, on serum testosterone level and seminal characteristics of Fars indigenous chickens wasstudied. PTU was fed between 7th to 13th weeks of age and semen was collected at weekly intervals, starting at 21st week of age and continued for seven weeks. The effect of PTU treatmen...
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