DRK, the Drosophila homolog of the SH2-SH3 domain adaptor protein Grb2, is required during signaling by the sevenless receptor tyrosine kinase (SEV). One role of DRK is to provide a link between activated SEV and the Ras1 activator SOS. We have investigated the possibility that DRK performs other functions by identifying additional DRK-binding proteins. We show that the phosphotyrosine-binding ...

Virtualization has become more important since cloud computing is getting more and more popular than before. There’s an increasing demand for security among the cloud customers. AMD plans to provide Secure Encrypted Virtualization (SEV)​[8] technology in its latest processor EPYC to protect virtual machines by encrypting its memory but without integrity protection. In this paper, we analyzed th...

Transportation system has a close bearing on the prosperity of society. However, transportation infrastructures are highly vulnerable to extreme events. Therefore, identifying most critical component is among first priorities network planners and managers. This paper proposes novel framework identify for road system. A key characteristic vulnerability assessment travelers’ response changes in t...

Many tropical peatlands are subjected to artificial drainage that leads degradation. Hence, hydrological restoration has recently been prioritized. Nevertheless, as field monitoring data limited, little is known about how measures, such ditch dams and bunds, can regulate peatland water tables. We used a hydrodynamic model —DigiBog_Hydro— simulate the effectiveness of bunds across three El Niño–...

As infection with wild-type (wt) Sendai virus (SeV) normally activates beta interferon (IFN-beta) very poorly, two unnatural SeV infections were used to study virus-induced IFN-beta activation in mouse embryonic fibroblasts: (i) SeV-DI-H4, which is composed mostly of small, copyback defective interfering (DI) genomes and whose infection overproduces short 5'-triphosphorylated trailer RNAs (pppR...

The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO-DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this study. Anesthesia was induced with propofol and maintained...

Entry of most paramyxoviruses is accomplished by separate attachment and fusion proteins that function in a cooperative manner. Because of this close interdependence, it was not possible with most paramyxoviruses to replace either of the two protagonists by envelope glycoproteins from related paramyxoviruses. By using reverse genetics of Sendai virus (SeV), we demonstrate that chimeric respirat...

We consider L-functions \(L_1,\ldots ,L_k\) from the Selberg class which have polynomial Euler product and satisfy Selberg’s orthonormality condition. show that on every vertical line \(s=\sigma +it\) with \(\sigma \in (1/2,1)\), these simultaneously take large values of size \(\exp \left( c\frac{(\log t)^{1-\sigma }}{\log \log t}\right) \) inside a small neighborhood. Our method extends to =1\...