objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

systematic studies on the vapor-liquid equilibria (vle) and conductometric properties of aqueous solutions of model surface-active ionic liquid 1-dodecyl-3-methylimidazolium bromide ([c12mim]br) are performed in the absence and presence of a large series of electrolytes in order to achieve a deeper understanding about the molecular mechanism behind the specific salt effect on the aggregation be...

Protein aggregation is phenomenon wherein protein loses its native structure and aggregates due to the adaption of non-native conformation. Amyloid aggregation formed by the accumulation of various proteins causes many diseases in humans and other organisms. Antioxidants can prevent proteins aggregation. Pulicaria undulata  extract along with phenolic compounds can increase protein stability an...

platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of cerastes persicus fieldi and echis carinatus were investigated. the partial fractionation was performed on a sephadex g-100 column. two fractions separated from cerastes persicus fieldi showed anti platelet aggregation activity on adp (200 µm)-induced platelet aggregation (ca 80% inhibi...

Understanding the microscopic dispersion and aggregation of nanoparticles at nanoscale media has become an important challenge during the last decades. Nanoscale modeling techniques are the important tools to tackle many of the complex problems faced by engineers and scientists. Making progress in the investigations at nanoscale whether experimentally or computationally has helped understand th...

A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...

aggregation operators (aos) have been studied by many schol- ars. as many aos are proposed, there is still lacking approach to classify the categories of ao, and to select the appropriate ao within the ao candidates. in this research, each ao can be regarded as a cognitive style or individual dierence. a cognitive style and aggregation operator (csao) model is pro- posed to analyze the mapping ...

Background: Patients undergoing cardiac surgery are at increased risk of bleeding due to multifactorial coagulopathies. In the present study, we aimed at investigating the changes in platelet count and function during and after surgery as well as determining the association of the platelet dysfunction with bleeding and transfusion requirements in these patients.    Methods: A total o...

to study the resistance to standard dosage of clopidogrel among iranian patients following percutaneous coronary intervention measured by platelet aggregation test.patients undergoing percutaneous coronary intervention in imam hussein medical center, tehran, iran, who were under treatment with aspirin, but had no history of clopidogrel usage, entered the study. patients received standard dosage...

This study was performed to assess the clopidogrel activity in inhibition of platelet aggregation in suspected angina patients on a daily dosag of 75 mg of clopidogrel for at least 7 days. This clinical trial was conducted in the outpatients department of Cardiology, Post graduate Medical Institute, Lady Reading Hospital, Peshawar from 15th October 2007 to 20th December 2007. We included 105 su...