Hepatic steatosis predisposes the liver to cold ischemia-warm reperfusion (CI/WR) injury by unclear mechanisms. Because hepatic steatosis has recently been associated with a lysosomal pathway of apoptosis, our aim was to determine whether this cell-death pathway contributes to CI/WR injury of steatotic livers. Wild-type and cathepsin B-knockout (Ctsb(-/-)) mice were fed the methionine/choline-d...

Background: The impact of hepatic steatosis on bioenergetics following hepatic ischemia-reperfusion injury (IRI) remains controversial and is associated with variable reports on its outcome. Large numbers of studies have been published examining the relationship between hepatic steatosis and cellular bioenergetics following hepatic IRI. This systematic review evaluates these studies. Methods: A...

AMA Płatek A, Szymańska J. The impact of fasting on cardiovascular risk control in patients with metabolic dysfunction-associated steatotic liver disease. Gastroenterology Review/Przegląd Gastroenterologiczny. 2023. doi:10.5114/pg.2023.131394. APA Płatek, A., & Szymańska, (2023). https://doi.org/10.5114/pg.2023.131394 Chicago Anna E., and Julia A. Szymańska. "The disease". Harvard MLA E. et al....

BACKGROUND Chemotherapy with L-asparaginase is associated with hepatotoxicity resulting in organ dysfunction in patients with preexisting liver disorders. This study investigated the protective effect of L-carnitine during chemotherapy in a steatotic rat liver model. METHODS Livers from nonsteatotic and steatotic rats were tested in an isolated liver reperfusion model adding L-asparaginase an...

We publish six CLINICAL SCIENCE REPORTS, two other BASIC RESEARCH ARTICLES AND 2 REVIEWS. LACAZE et al. evaluated musculoskeletal discomfort and mental and physical fatigue in 64 call-center workers of an airline company before and after a supervised exercise program compared with rest breaks during the work shift and found that the discomfort decreased significantly for the spine and buttocks ...

A number of new approaches to measure the viscoelastic properties of the liver are now available to clinicians, many involving shear waves. However, we are at an early stage in understanding the physical processes that govern shear wave propagation in normal liver, with more unknowns added when pathologies such as steatosis are present. This technical note focuses on what is known about the cha...

Chronic hepatic injury is accompanied by a ductular response that is strongly correlated with disease severity and progression of fibrosis. To investigate whether anti-inflammatory drugs can modulate the ductular response, we treated mice suffering from a steatotic or cholestatic injury with anti-TNF-α antibodies (Infliximab) or glucocorticoids (Dexamethasone). We discovered that Dexamethasone ...