Carcinoma of breast is a common cancer in women. Prognosis of breast carcinoma is assessed using steroid receptor status and Her 2 neu amplification. Steroid receptors, when present denotes a favourable clinical outcome and has also been used to determine whether a patient benefits from adjuvant therapy [1]. Her 2 neu amplification is associated with a poor prognosis [2]. Furthermore, Her 2 neu...

The brain is an important target organ for circulating steroid hormones secreted from peripheral organs such as the adrenal cortex, testis and/or ovary. In other words, these peripheral organs control the central nervous system. Steroid hormones substantially influence brain development, reproduction, sexual differentiation, cognition, memory, behavior, and so on. These effects are mediated by ...

Oestradiol and progesterone act in the brain to elicit profound effects on behaviour and physiology. One physiological function of oestradiol is the induction of progesterone receptor (PR) expression in a variety of behaviourally relevant brain regions, including the ventromedial nucleus of the hypothalamus (VMN), the medial preoptic nucleus of the preoptic area (MPOA), the arcuate nucleus (ARC...

to determine the prognostic value of response to treatment in patients with focal segmental glomerulo-sclerosis. fsgs includes 10-15% of idiopathic nephrotic syndrome in children. bulk of evidence supports disease relationship with immune system. unfortunately, responses to immunosuppressive drugs are not desirable and progression to end-stage renal disease is common. we analyzed 62 out of 99 c...

Antibodies against steroid hormones can be used to eliminate steroid binding to serum proteins and to cellular proteins which are normally not considered to be steroid receptors. Since binding of sex steroids and of some glucocorticoids to their cellular receptor proteins does not appear to be affected by the antibodies, the latter may be used for qualitative and quantitative characterization o...