INTRODUCTION Non-steroidal anti-inflammatory drugs and corticosteroids are both used in the treatment acute gouty arthritis and may adversely interact with colchicine. Gastrointestinal toxicity of colchicine is dose-dependent and can be aggravated by drug-drug and drug-patient interactions. CASE PRESENTATION Colonic perforation associated with second-line administration of colchicine for acut...

Eleven patients with osteoarthritis and mild hypertension completed an 8-week, double-blind crossover study in which 200 mg tiaprofenic acid 3-times daily or placebo were substituted for their normal non-steroidal anti-inflammatory therapy. Systolic blood pressure was significantly higher on tiaprofenic acid therapy than on placebo and plasma renin activity was significantly lower on active tre...

Non-steroidal anti-inflammatory drugs are currently being investigated as agents to reduce the incidence and progression of Alzheimer's disease. Paradoxically they have also been reported to induce deleterious effects on the central nervous system, including aseptic meningitis and cognitive decline in the elderly. We report a case of a 72-year-old woman who presented with a 6-week history of pr...

a 78-year-old woman presented with epigastric pain following the use of non-steroidal anti-inflammatory drugs (nsaids) for joint pain relief. she underwent ugi endoscopy. during ugi endoscopy she suffered from severe retching despite the use of sedatives. at 6 hours after the procedure, she developed raccoon eyes with chemosis. biopsy from the gastrointestinal (gi) mucosa revealed amyloidosis.