نتایج جستجو برای: steroidogenic acute regulatory star gene

تعداد نتایج: 1780110  

Journal: :The Journal of Clinical Endocrinology & Metabolism 1996

2003
Wen-Jun Shen Shailja Patel Vanita Natu Richard Hong Jenny Wang Salman Azhar Fredric B. Kraemer

Hormone-sensitive lipase (HSL) is responsible for the neutral cholesteryl ester hydrolase activity in steroidogenic tissues. Through its action, HSL is involved in regulating intracellular cholesterol metabolism and making unesterified cholesterol available for steroid hormone production. Steroidogenic acute regulatory protein (StAR) facilitates the movement of cholesterol from the outer mitoch...

Journal: :Endocrinology 2002
Makoto Kusakabe Takashi Todo H James McQuillan Frederick W Goetz Graham Young

Complementary DNA-encoding proteins with high homology to steroidogenic acute regulatory proteins (StAR) of mammals were cloned from rainbow trout head kidney and a mixture of several brook trout tissues. A cDNA encoding an MLN64 homolog was also cloned from brook trout. The C-terminal domains of rainbow trout StAR and brook trout StAR were very highly conserved compared with StAR of mammals. I...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2010
Mei-Chih Chen Shyi-Wu Wang Shu-Fen Kan Shiow-Chwen Tsai Yu-Ching Wu Paulus S Wang

Propylthiouracil (PTU) is a common and effective clinical medicine for the treatment of hyperthyroidism. Our previous study demonstrated that short-term treatment with PTU inhibits progesterone production in rat granulosa cells. However, our present results indicate that a 16-h treatment with PTU was able to stimulate pregnenolone production in rat granulosa cells, although progesterone product...

Journal: :Environmental toxicology and chemistry 2007
Ling Ding Margaret B Murphy Yuhe He Yan Xu Leo W Y Yeung Jingxian Wang Bingsheng Zhou Paul K S Lam Rudolf S S Wu John P Giesy

Brominated flame retardants (BFRs) and brominated dioxins are emerging persistent organic pollutants that are ubiquitous in the environment and can be accumulated by wildlife and humans. These chemicals can disturb endocrine function. Recent studies have demonstrated that one of the mechanisms of endocrine disruption by chemicals is modulation of steroidogenic gene expression or enzyme activiti...

2011
F Spiga Y Liu G Aguilera S L Lightman

The availability of active steroidogenic acute regulatory protein (StAR) and side-chain cleavage cytochrome P450 (P450scc) are rate-limiting steps for steroidogenesis. Transcription of StAR and P450scc genes depends on cyclic AMP-response element-binding protein (CREB) phosphorylation and CREB co-activator, transducer of regulated CREB activity (TORC), which is regulated by salt-inducible kinas...

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