Microsatellites are multi-allelic and composed of short tandem repeats (STRs) with individual motifs composed of mononucleotides, dinucleotides or higher including hexamers. Next-generation sequencing approaches and other STR assays rely on a limited number of PCR amplicons, typically in the tens. Here, we demonstrate STR-Seq, a next-generation sequencing technology that analyses over 2,000 STR...

Two new species of the cyrtoscydmine ant-like stone beetle genus Syndicus are described: S. (s. str.) birmanicus sp. n. (from Myanmar) and S. (Semisyndicus) chiangmaianus sp. n. (from Thailand). A previously unknown male of S. (s. str.) puncticollis Jałoszyński is described, and for the first time the spermatheca of S. (Semisyndicus) sumatrensis Schaufuss is illustrated. Syndicus puncticollis, ...

Stromelysin-3 (STR-3) is a recently characterized matrix metalloproteinase i MMI'i that was cloned on the basis of differential expression in benign and malignant breast tumors. This M Ml' has a unique processing mechanism and substrate specificity. Unlike previously characterized MMi's that are secreted as inactive zymogens, STR-3 is processed within the constitutive secretory pathway and secr...

BACKGROUND Since 2004, treatment of Mycobacterium ulcerans disease, or Buruli ulcer, has shifted from surgery to daily treatment with streptomycin (STR) + rifampin (RIF) for 8 weeks. For shortening treatment duration, we tested the potential of daily rifapentine (RPT), a long-acting rifamycin derivative, as a substitute for RIF. METHODOLOGY/PRINCIPAL FINDINGS BALB/c mice were infected with M....

1Department of Pediatrics and Medical Genetics, Medical University, Plovdiv Vasil Aprilov 15-A Str., Plovdiv 4002, Bulgaria 2University Hospital “St. George” Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria 3Psychiatric ward for active treatment of men, State Phsychiatry Hospital Pazardzhik, 28 Bolnichna Str. 4400 Pazardzhik, Bulgaria 4Department of Plant Phisyology and Molecular Biolo...

Abstract Psychostimulants such as amphetamine (AMPH) target dopamine (DA) neuron synapses to engender drug-induced plasticity. While DA neurons modulate the activity of striatal (Str) cholinergic interneurons (ChIs) with regional heterogeneity, how AMPH affects ChI has not been elucidated. Here, we applied quantitative fluorescence imaging approaches map dose-dependent effects a single dose on ...

BACKGROUND AND OBJECTIVE The aim of this study was to evaluate and compare various parameters between complete and incomplete ST-segment resolution (STR) patients' groups and to identify associates of STR in patients with acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI) (primary outcome). MATERIALS AND METHODS A total of 203 cons...

STR/N is an inbred strain of mice which is known to exhibit extreme polydipsia and polyuria. We previously found central administration of angiotensin II enhanced cardiovascular responses in STR/N mice than normal mice, suggesting that STR/N mice might exhibit different cardiovascular responses. Therefore, in this study, we investigated daily mean arterial blood pressure and heart rate, and cha...

Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA, ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are considered to be involved in conferring resistance to streptomycin (STR) in Mycobacterium tuberculosis. The aim of this study was to investigate the spectrum and frequency of these mutations in M. tuberculosis clinical isolates, bo...

Short tandem repeats (STRs) have a wide range of applications, including medical genetics, forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to profile hundreds of thousands of STR loci. However, mainstream bioinformatics pipelines are inadequate for the task. These pipelines treat STR mapping as gapped alignment, which results in cumbersome processing times a...