A unified controlled medical vocabulary has been cited as one of the grand challenges facing Medical Informatics. We would restate this challenge as ‘achieving a re-usable and application-independent representation of medical concepts.’ Achieving a re-usable representation of medical concepts is a pre-requisite for meeting two key strategic goals of the next decade of the development in medical...

Fi rms in the LDCs need to adopt and indige n i ze tra n s fe rred tech n o l ogy befo re u s age. The adoption costs depend on the state of the infra s t ru c t u re and on the l o c a l i zed spillover effects ge n e rated by a rival fi rm. In this context, the pap e r examines the timing of such technological adoption. It shows that strategic decisions regarding time may result in a “waiting...

INTRODUCTION Some micro arteriovenous malformations (AVMs) located in deep brain are undetectable. How to choose a proper timing to detect these AVMs remains unclear. CASE DESCRIPTION A 21-year-old male patient was admitted to our center for intraventricular haematoma. Digital subtraction angiographies (DSAs) were performed one week and one month respectively after his haemorrhage, but no pos...

The aim of this paper is to provoke a thoughtful re-evaluation of our assumptions regarding the health consequences of elective ovariohysterectomy in pet dogs. It proposes that we might re-shape our thinking about the physiological impact of the timing of spaying and commit ourselves to making spaying a strategic physiological disturbance. Several observations that may help to guide this re-sha...

Strategic design and multi-objective optimisation of distribution networks based on genetic algorithms Vitoantonio Bevilacqua a , Nicola Costantino b , Mariagrazia Dotoli a , Marco Falagario b & Fabio Sciancalepore b a Dipartimento di Elettrotecnica ed Elettronica, Politecnico di Bari, Via Re David 200, Bari, 70125, Italy b Dipartimento di Ingegneria Meccanica e Gestionale, Politecnico di Bari,...

My submission, #4 (9/28/2009, archived online at www.policyscience.net) for your study group urged global health as a new area with emerging, extraordinary opportunities for US leadership, accelerating progress, and strengthening shared humanitarian concerns. As you may recall, I enclosed a copy of a letter of July 21, 2009 to Stephen Groft at NIH re ideas for a Rapid-Learning International Hea...

This paper provides a theoretically grounded framework for designing and analysing business models for ICT services, products and systems. It critically revisits the most topical literature on business modelling, as well as general strategic management, industrial organisation and network economics literature. Business model design is interpreted as the (re)configuration of control parameters o...