The septal area is an important anterior component of the limbic system. It is located on the medial surface of the cerebral hemisphere nestled inferior to the rostrum of the corpus callosum and anterior to the third ventricle and lamina terminalis (Fig 1) (1). This small area is contiguous with components of the limbic system curving around the corpus callosum (Fig 2) as well as structures on ...

2 Connectivity between the central nucleus of the amygdala 3 and the bed nucleus of the stria terminalis in the non-human 4 primate: neuronal tract tracing and developmental neuroimaging 5 studies 6 Jonathan A. Oler • Do P. M. Tromp • Andrew S. Fox • Rothem Kovner • Richard J. Davidson • 7 Andrew L. Alexander • Daniel R. McFarlin • Rasmus M. Birn • Benjamin Berg • 8 Danielle M. deCampo • Ned H....

Abstract Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability responses to is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how altered a shock-plus-sound stressor with between-group yoked design, where participants in controllable uncontrollable groups experienced matched exposure. Emp...

Inactivation of the maternally imprinted, paternally expressed gene 3 (Peg3) induces deficits in olfactory function, sexual and maternal behaviors, oxytocin neuron number, metabolic homeostasis and growth. Peg3 is expressed in a number of developing hypothalamic and basal forebrain structures and is a component of the P53 apoptosis pathway. Peg3 inactivation in neuronal cell culture lines inhib...

This study tested the effects of 8 days of subchronic administration of 3,4-methylene dioxymethamphetamine (MDMA) (5 mg/kg b.w.) on preprotachykinin A mRNA levels in discrete rat brain regions. In situ hybridization examined preprotachykinin A mRNA levels in the core and shell of the nucleus accumbens, the islands of Calleja, the olfactory tubercle, the dorsal and ventral caudate-putamen, the b...

The amplitude of the acoustic startle response is reliably enhanced when elicited in the presence of bright light (light-enhanced startle) or in the presence of cues previously paired with shock (fear-potentiated startle). Light-enhanced startle appears to reflect an unconditioned response to an anxiogenic stimulus, whereas fear-potentiated startle reflects a conditioned response to a fear-elic...

BACKGROUND AND PURPOSE The effect of exposing the developing brain of a high school football player to subconcussive impacts during a single season is unknown. The purpose of this pilot study was to use diffusion tensor imaging to assess white matter changes during a single high school football season, and to correlate these changes with impacts measured by helmet accelerometer data and neuroco...

Food intake activates neurones expressing prolactin-releasing peptide (PrRP) in the medulla oblongata and oxytocin neurones in the hypothalamus. Both PrRP and oxytocin have been shown to have an anorexic action. In the present study, we investigated whether the activation of oxytocin neurones following food intake is mediated by PrRP. We first examined the expression of PrRP receptors (also kno...

Cholinergic and GABAergic corticopetal neurons in the basal forebrain play important roles in cortical activation, sensory processing, and attention. Cholinergic neurons are intermingled with peptidergic, and various calcium binding protein-containing cells, however, the functional role of these neurons is not well understood. In this study we examined the expression pattern of secretagogin (Sc...