BACKGROUND Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown. Encephalopathy is a less common presentation; it has been suggested it is related to migraine. We characterised migraine patterns and treatment responses in CADASIL, ...

Migraine and stroke are common, disabling neurologic disorders, with a high socioeconomic burden. A link between them has been proposed years ago, and various theories have been proposed to explain this bidirectional relation. However, the precise causes remain unclear. We briefly summarize existing hypotheses of this correlation seeking for recommendations for stroke prevention in migraineurs,...

BACKGROUND Observational data have reported associations between patent foramen ovale (PFO), cryptogenic stroke and migraine. However, randomized trials of PFO closure do not demonstrate a clear benefit either because the underlying association is weaker than previously suggested or because the trials were underpowered. In order to resolve the apparent discrepancy between observational data and...

Background: Migraine and tension-type headache are primary headache disorders that occur during pregnancy. Most women with migraine improve during pregnancy. Some women have their first attack during pregnancy. Migraine can recur postpartum; it can also begin at that time. Women who have had menstrual migraine and migraine onset at menarche tend to experience no migraine during pregnancy. Not a...

BACKGROUND AND PURPOSE The objective was to investigate the role of C677T MTHFR polymorphism in migraine pathogenesis and in the migraine-ischemic stroke pathway. METHODS A first genotype-migraine association study was conducted on 100 patients with migraine with aura (MA), 106 with migraine without aura (MO), and 105 subjects without migraine, which provided evidence in favor of association ...

cadasil (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is characterized by a history of migraine headaches (30%-40% of individuals), mid-adult (30s-60s) onset of cerebrovascular disease progressing to dementia, and diffuse white matter lesions and subcortical infarcts on neuroimaging. cadasil is an autosomal dominant disorder whose gene, notch3, is ...

BACKGROUND AND PURPOSE Migraine with aura is an established stroke risk factor, and excitatory mechanisms such as spreading depression (SD) are implicated in the pathogenesis of both migraine and stroke. Spontaneous SD waves originate within the peri-infarct tissue and exacerbate the metabolic mismatch during focal cerebral ischemia. Genetically enhanced SD susceptibility facilitates anoxic dep...

BACKGROUND AND PURPOSE Headache is a common symptom in acute ischemic and hemorrhagic stroke, but many aspects of its association with other clinical factors are controversial. METHODS We analyzed characteristics of headache symptoms at stroke onset and associations between headache at stroke onset and at several clinical parameters in 2196 patients experiencing ischemic stroke or transient i...

involvement of early spasm since recovery after CSD/CSD-like depolarizations is energy dependent. The occurrence of DIND despite proper fluid management and nimodipine prophylaxis in our patients is interesting because migraine with aura is a known risk factor for ischemic stroke in young women.6 A particular link has been proposed between migrainous stroke-related mechanisms and DIND.7 In conc...

Background Phosphodiesterase 5 (PDE5) is associated with migraine pathophysiology, stroke recovery and vasospasm treatment [1,2]. We have shown previously that vasodilatation was not a prerequisite for migraine induction; sildenafil elicited migraine-like attacks in migraine patients without measurable changes in intraor extracerebral artery diameter. Further, sildenafil was found to not affect...