BACKGROUND This study aimed to evaluate whether treatment with sodium valproate (SV) was associated with reduced risk of stroke or myocardial infarction (MI). METHODS Electronic health records data were extracted from Clinical Practice Research Database for participants ever diagnosed with epilepsy and prescribed antiepileptic drugs. A nested case-control study was implemented with cases diag...

INTRODUCTION In ICUs, fluid administration is frequently used to treat hypovolaemia. Because volume expansion (VE) can worsen acute respiratory distress syndrome (ARDS) and volume overload must be avoided, predictive indicators of fluid responsiveness are needed. The purpose of this study was to determine whether passive leg raising (PLR) can be used to predict fluid responsiveness in patients ...

BACKGROUND A dynamic preload index such as stroke volume variation (SVV) is not as reliable in spontaneous breathing (SB) patients as in mechanically ventilated patients. This study examined the hypothesis that spectral analysis of hemodynamic variables during paced breathing (PB) activity may be a feasible index of volume changes and fluid responsiveness, despite insufficient respiratory chang...

Perioperative goal directed therapy (GDT) based on measurement of stroke volume (SV) is expected to improve postoperative outcome1). A device that can accurately measure stroke volume (SV) during surgery and that is both minimally-invasive and low cost is ideal. Many methods have been developed to measure SV less-invasively and continuously; pulse contour and intrathoracic impedance methods hav...

BACKGROUND Orthostatic intolerance after bed rest is characterized by hypovolemia and an excessive reduction in stroke volume (SV) in the upright position. We studied whether the reduction in SV is due to a specific adaptation of the heart to head-down tilt bed rest (HDTBR) or acute hypovolemia alone. METHODS AND RESULTS We constructed left ventricular (LV) pressure-volume curves from pulmona...

• The sudden injection indicator dilution method for the estimation of ventricular volumes J has been applied both in the experimental animal ~ and in man.This method presupposes effective uniform distribution of indicator in each end diastolic volume (EDV), a circumstance which may not occur. Further, it has not yet been practical to evaluate in vivo the possible effects of "nonmixing" on the ...

BACKGROUND Cardiovascular magnetic resonance (CMR) is an emerging modality in the diagnosis and follow-up of patients with pulmonary arterial hypertension (PAH). Derivation of stroke volume (SV) from the pulmonary flow curves is considered as a standard in this respect. Our aim was to investigate the accuracy of pulmonary artery (PA) flow for measuring SV. METHODS Thirty-four PAH patients und...

AIMS This study was designed to investigate the mechanisms by which the right ventricle is able to increase stroke volume (SV) during exercise in chronic obstructive pulmonary disease (COPD). A second aim was to determine whether resting pulmonary artery pressure (Ppa) is predictive of exercise SV. METHODS 16 COPD patients (GOLD stages II-IV) underwent right heart catheterisation at rest and ...

Euhydrated and dehydrated subjects exercised in a hot and a cold environment with our aim to identify factors that relate to reductions in stroke volume (SV). We hypothesized that reductions in SV with heat stress are related to the interaction of several factors rather than the effect of elevated skin blood flow. Eight male endurance-trained cyclists [maximal O(2) consumption (VO(2 max)) 4.5 +...