نتایج جستجو برای: sub chronic toxicity
تعداد نتایج: 808881 فیلتر نتایج به سال:
LAUDEXIUM METHYLSULPHATE (Laudolissin) is a synthetic curarizing agent (Taylor and Collier, 1951) used in prolonged surgical operations. We have previously described some of its pharmacological properties (Collier and Macauley, 1952) and the purpose of the present paper is to report a further exploration of its pharmacology in relation to its clinical use. As Bovet (1951) has stressed, the toxi...
Although doxorubicin (DOX) is a very effective antineoplastic agent, its clinical use is limited by a dose-dependent, persistent and cumulative cardiotoxicity, whose mechanism remains to be elucidated. Previous works in animal models have failed to use a multi-organ approach to demonstrate that DOX-associated toxicity is selective to the cardiac tissue. In this context, the present work aims to...
BACKGROUND & OBJECTIVES Pre-clinical toxicology evaluation of biotechnology products is a challenge to the toxicologist. The present investigation is an attempt to evaluate the safety profile of the first indigenously developed recombinant DNA anti-rabies vaccine [DRV (100 μg)] and combination rabies vaccine [CRV (100 μg DRV and 1.25 IU of cell culture-derived inactivated rabies virus vaccine)]...
Capparis sepiaria Linn. (Family: Capparidaceae) is a rare indigenous in South India but has widespread distribution in many tropical and sub-tropical countries. The present study intended with various phytochemical screening and toxicity studies were carried out on the leaves of the Capparis sepiaria. Preliminary phytochemical evaluation of the ethanolic extract of revealed that the presence of...
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