Nitric oxide (NO) is normally synthesized inside skeletal muscle fibers by both endothelial (eNOS) and neuronal (nNOS) nitric oxide synthases. In this study, we evaluated the influence of hypobaric hypoxia on the expression of NOS isoforms, argininosuccinate synthetase (AS), argininosuccinate lyase (AL), and manganese superoxide dismutase (Mn SOD) in the ventilatory muscles. Rats were exposed t...

BACKGROUND Sepsis or peritonitis impairs diaphragmatic contractility and endurance capacity. Peroxynitrite, a powerful oxidant formed by superoxide and nitric oxide, has been implicated in the pathogenesis. Propofol scavenges this reactive molecule. The authors conducted the current study to evaluate whether propofol prevents diaphragmatic dysfunction induced by septic peritonitis. METHODS Fo...

INTRODUCTION Controlled mechanical ventilation (CMV) induces profound modifications of diaphragm protein metabolism, including muscle atrophy and severe ventilator-induced diaphragmatic dysfunction. Diaphragmatic modifications could be decreased by spontaneous breathing. We hypothesized that mechanical ventilation in pressure support ventilation (PSV), which preserves diaphragm muscle activity,...

Subphrenic abscess though a common presentation itself encountered in surgical practice due to various cause, tubercular subphrenic the absence of coexisting tuberculous abdomen presenting as complication pulmonary tuberculosis is extremely rare. Only very few cases have been reported an extrapulmonary manifestation so far. We report case isolated sub-diaphragmatic which responded well with ant...

Perioperative necessity of deep sedation is inevitably associated with diaphragmatic inactivation. This study investigated 1) the feasibility of a new phrenic nerve stimulation method allowing early diaphragmatic activation even in deep sedation and, 2) metabolic changes within the diaphragm during mechanical ventilation compared to artificial activity. 12 piglets were separated into 2 groups. ...

Hepatic and diaphragmatic hexokinase (HK) activities increased in fetuses of rats developed under maternal hyperglycemic conditions, compared to those in normal controls. In those organs, Type I and Type II hexokinase isozymes were detected by electrophoresis and densitometry with a chromatoscanner. Densitometric peak that corresponded to hepatic and diaphragmatic Type II hexokinase was also in...

Gastric perforation in neonates is an uncommon condition. A four-day-male neonate was referred with respiratory distress, abdominal distention, right scrotal swelling and extensive emphysema of the abdominal wall. Abdominal X-ray findings showed bilateral sub-diaphragmatic free air, right scrotal pneumatocele and subcutaneous emphysema of the abdominal wall. During the operation, pre-pyloric pe...

A 72 years old non smoker patient had PET-CT exploration for left lung cancer. It highlighted an unexpected sub diaphragmatic fixation. The abdominal CT scan highlighted a small size formation, hyper vascular, located at the right side of the abdominal aorta, close to the ostium of the inferior mesenteric artery. The diagnosis of paraganglioma of the Zuckerk and l body was suspected and confirm...

Purpose To evaluate the compatibility and correlation between noninvasive surface respiratory electromyography and invasive transesophageal diaphragmatic electromyography measurements as facilitating indicators of neural respiratory drive (NRD) evaluation during treadmill exercise. Patients and methods Transesophageal diaphragmatic electromyogram activity (EMGdi,es) and surface inspiratory el...