Many studies have confirmed the traditional use of Ximenia americana (Olacaceae). Its different parts, leaf, fruit, roots, stem bark and root showed pharmacological potentials. X. is a plant which possessed antibacterial, antidiabetic, antiviral anticancer properties. The present study was undertaken to evaluate oral acute subchronic toxicity hydroethanolic extract on Sprague Dawley rats. In te...

the aim of this investigation was to design and develop nanoemulsions as novel delivery systems for rapamycin. phase behavior of quaternary systems composed of traicetin (as oil), various surfactants and co-surfactants and water at different surfactant/co-surfactant weight ratios were investigated by the construction of phase diagrams. formulations were taken from the o/w ne region of the phase...

_Clematis hirsuta_ leaves and _Rhamnus prinoides_ roots have a long history of medicinal use in Nyeri County, Kenya. However, there is no evidence to back up their safety. The acute subacute toxicity aqueous leaf root extracts _Wistar_ rats was investigated this study. Changes body weight, feed water consumption were used as indicators the study, while changes biochemical hematological paramete...

Objective(s):The aim of this study was to determine whether technetium (99mTc) uptake is a relevant method for the differential diagnosis of Graves disease and subacute thyroiditis and calculate its cutoff value in case of its relevancy. Methods: A total of 69 patients, who were followed up (>3 months) in our hospital for thyrotoxi...

background whooping cough is caused by bordetella pertussis, and it remains a public health concern. whole-cell pertussis vaccines have been commonly employed for expanded immunization. there is no doubt of the efficacy of whole cell pertussis vaccine, but it is necessary to improve the vaccine to decrease its toxicity. objectives in this study, an inactivation process of dealing with pertussis...

The erroneous assumption that herbal products is generally safe for consumption, a major factor leading to the increased of herb-induced liver injury (HILI). Even though Laurus nobilis or laurel commonly used spice, safety aspect its consumption under-studied. To bridge this gap knowledge, mutagenicity, acute toxicity, and subacute toxicity LAURESH®, which standardized leaf extract were evaluat...

Acute and subacute intraperitoneal doses of fumonisin B(1) (FB(1)) were administered to test the efficacy of the FB(1)-glucose reaction products in detoxifying FB(1) in swine. In the acute study at 11 mumol of FB(1)/kg of body weight, five of six pigs administered FB(1) and four of six pigs administered FB(1)-glucose died from acute pulmonary edema. Analysis of weight gain, serum aspartate amin...

BACKGROUND Red ginseng oil (RGO) is produced by supercritical CO2 extraction of secondary products derived from Korean Red Ginseng extract. As the use of RGO has increased, product safety concerns have become more important. METHODS In the present study, the subacute oral toxicity and bacterial reverse mutagenicity of RGO were evaluated. Sprague-Dawley rats were orally administered with RGO f...