Starting from succinic anhydride and 2-methylanisole, a chemoenzymatic collective formal/total synthesis of several optically active tetrahydronaphthalene based bioactive natural products has been presented via advanced level common precursors; the natural product and antipode (-)/(+)-aristelegone B. Regioselective benzylic oxidations, stereoselective introduction of hydroxyl groups at the α-po...

1 Plant Polymer and 2 Biomaterials Processing Research Units, National Center for Agricultural Utilization Research, Agricultural Research Service, U.S. Department of Agriculture, 1815 N. University St., Peoria, IL 61604. 3 Department of Chemistry, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854; current address:Department of Chemistry, Rutgers University, 610 Taylor...

The ring contraction-lactamisation of anhydrides upon reaction with trimethylsilylazide in the presence an amine catalyst has been studied. Under controlled conditions, 5,- 6- and 8-membered lactams can be generated from cyclic operationally simple procedure. In case ?-lactams, methodology allows for synthesis challenging systems incompatible usual disconnection involving activated carbonyl gro...

Materials: Glycol chitosan (GCS, Mw = 200 kDa; degree of deacetylation = 90%), potassium persulfate, sodium borohydride, succinic anhydride, melittin from bee venom, sodium dodecyl sulfate, D-(+)-trehalose dehydrate, N-succinimidyl 3-[2-pyridyldithio]-propionate (SPDP), tris(2carboxyethyl)phosphine (TCEP), triethlyl amine (TEA), ethylenediaminetetraacetic acid (EDTA), and dimethyl sulfoxide (DM...

Templated mineralization of virus particles provides routes to narrowly dispersed nanoparticles that are not readily prepared by other means. The templated mineralization of metal or metal oxide on the external surface of wild-type cowpea mosaic virus (CPMV), a plant virus, is facilitated by increasing the external surface negative charge. This is achieved by the chemical modification of surfac...

Oligodeoxynucleotide (ODN) conjugates with the polylysine comb-type copolymer having an ability to promote and stabilize duplex and triplex DNA formation were prepared. 5'-Aminated ODN was succinylated with succinic anhydride. The resulting ODNs having carboxyl terminus were coupled with epsilon-amino groups of the comb-type copolymer using water soluble carbodiimide. The conjugate free from un...