A 25-year-old woman with no cardiovascular risk factors was admitted to our hospital with dyspnea and palpitations during the last two months. Physical examination showed blood pressure of 150/50 mm Hg and a continuous murmur across the precordium in cardiac auscultation was observed. The 12 leads electrocardiogram was normal. Chest X-ray showed a slight cardiomegaly. The transthoracic echocard...

SVA is a composite repetitive element named after its main components, SINE, VNTR and Alu. We have identified 2762 SVA elements from the human genome draft sequence. Genomic distribution analysis indicates that the SVA elements are enriched in G+C-rich regions but have no preferences for inter- or intragenic regions. A phylogenetic analysis of the elements resulted in the recovery of six subfam...

BACKGROUND Senecavirus A (SVA), a member of the family Picornaviridae, genus Senecavirus, is a recently identified single-stranded RNA virus closely related to members of the Cardiovirus genus. SVA was originally identified as a cell culture contaminant and was not associated with disease until 2007 when it was first observed in pigs with Idiopathic Vesicular Disease (IVD). Vesicular disease is...

There have been few case reports on giant sinus of Valsalva aneurysm (SVA). We report a case of a giant unruptured right coronary SVA that was confused with a pericardial cyst by transthoracic echocardiography.

SystemVerilog Assertions (SVA), as well as Property Specification Language (PSL) are linear temporal logics based on LTL [14], extended with regular expressions and local variables. In [6] Bustan and Havlicek show that the local variable extensions, as well as regular expressions with intersection, render the verification problem of SVA and PSL formulae EXPSPACE-complete. In this paper we show ...

Method Twenty-six patients with DLKS underwent gait analysis using 3-dimentional motion analysis system (3D-MAS). Two reflection markers were attached to the skin surface on C7 and S1 spinous processes in all patients. Then they walked on treadmill at self-selected walking speed, and 3-dementional location of these surface makers (C7.S1) were recorded by synchronized 4 cameras that were placed ...

BACKGROUND PEGylation is a strategy used by the pharmaceutical industry to prolong systemic circulation of protein drugs, whereas formulation excipients are used for stabilization of proteins during storage. Here we investigate the role of PEGylation in protein stabilization by formulation excipients that preferentially interact with the protein. METHODOLOGY/PRINCIPAL FINDINGS The model prote...

Simvastatin hydroxy acid (SVA), the pharmacologically active form of simvastatin (SV), is a potent inhibitor of 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase and is formed on hydrolysis of the orally administered SV. In this article, we report the structural characterization of two new dihydroxy glutathione adducts and a trihydroxy derivative of SVA, all found in rat bile. Metabolite I ...

Simvastatin hydroxy acid (SVA), the pharmacologically active form of simvastatin (SV), is a potent inhibitor of 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase and is formed on hydrolysis of the orally administered SV. In this article, we report the structural characterization of two new dihydroxy glutathione adducts and a trihydroxy derivative of SVA, all found in rat bile. Metabolite I ...