The direct CH4 conversion (DMC) to methanol is a challenging topic. In this study, the Ru/SZ (sulfated zirconia) single-atom catalysts (SACs) were synthesized and utilized DMC under mild conditions (70 °C). yield over SACs (18.32 µmol, TOF ≥ 80 h–1) significantly exceeded sum of yields SZ (0.67 µmol) Ru/ZrO2 (0.29 µmol), indicating that new active center was formed on SACs. Combined with result...