Hydrogen sulfide (H2S) has emerged as an important biological signaling molecule in the last decade. During the growth of this field, significant controversy has arisen centered on the physiological concentrations of H2S. Recently, a monobromobimane (mBB) method has been developed for the quantification of different biologically-relevant sulfide pools. Based on the prevalence of the mBB method ...

The discovery of symbioses between marine invertebrates and sulfide-oxidizing bacteria at deep-sea hydrothermal vents and in other high-sulfide marine environments has stimulated research into the adaptations of metazoans to potentially toxic concentrations of sulfide. Most of these studies have focused on a particular action of sulfide--its disruption of aerobic metabolism by the inhibition of...

Hydrogen sulfide is the "third" gasotransmitter on the rise in cardiovascular research. Recent studies show that hydrogen sulfide has a great potential in the regulation of vascular tone of systemic arteries and many molecular targets are discussed. However, the complex mechanism of vascular tone regulation by hydrogen sulfide is only incompletely understood. It seems that a potent interaction ...

-Putrefactive hydrogen sulfide production in the upper 4 cm of sediment in two small freshwater and eutrophic Southeast Michigan, U.S.A., lakes ranged from 0.13 to 1.51 with an average of 0.46 mg S l-~ day-~. Sulfate reductive production of hydrogen sulfide at the same sites ranged from 0.7 to 3.2 with an average of 1.54 mg S 1~ dayt. Putrefactive hydrogen sulfide production represented 5.1-53°...

Hydrogen sulfide (H2S) impairs mitochondrial respiration by potently inhibiting the heme-copper cytochrome c oxidase. Since many prokaryotes, including Escherichia (E.) coli, generate H2S and encounter high H2S levels particularly in the human gut, herein we tested whether bacteria can sustain sulfide-resistant O2-dependent respiration. E. coli has three respiratory oxidases, the cyanide-sensit...

In this work, we synthesized a trypsin-stabilized fluorescent gold nanocluster. It was found that sulfide interacted with the nanocluster, which could result in significant fluorescence quenching. With this quenching effect, a fluorescence sulfide sensor was developed. This sensor responded linearly to sulfide in the range of 50 nM to 8 μM, and was capable of detecting sulfide as low as 5.5 nM....

Physiological and molecular phylogenetic approaches were used to investigate variation among 12 cyanobacterial strains in their tolerance of sulfide, an inhibitor of oxygenic photosynthesis. Cyanobacteria from sulfidic habitats were found to be phylogenetically diverse and exhibited an approximately 50-fold variation in photosystem II performance in the presence of sulfide. Whereas the degree o...

catalytic and photocatalytic reactions of (2-chloroethyl) phenyl sulfide (2-ceps), a mimic of bis (2-chloroethyl)  sulfide (i.e. sulfur mustard) were studied on the surfaces of titanium oxide. tio2 nanoparticles (anatase, rutile and mixture of 80% anatase/20% rutile) along with bulk tio2 were tested as reactive sorbents for reaction of 2-ceps at room temperature (25±0.5°c). reactions were monit...

Rates of nitrogen dioxide (NO2) absorption and sulfide oxidation were measured in a highly characterized stirred cell contactor at 55 °C, with O2 present in the gas phase. The rate constant of the reaction between NO2 and sul-fide at 55 °C was determined to be 26.4 x105 M-1sec-1. A reaction mechanism was proposed that is consistent with the kinetic data. NO2 absorption initiates sulfide oxidati...

Sulindac is the most extensively investigated clinically relevant chemopreventive nonsteroidal anti-inflammatory drug. Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediate its antitumorigenic effects by inducing apoptosis. Recent evidence suggests that sulindac sulfide engages the mitochondrial pathway involving caspase 9 and Bax to mediate its apoptotic effe...