Incontinentia pigmenti (IP; Bloch-Sulzberger syndrome) is a rare, genetic syndrome inherited as an X-linked dominant trait. It primarily affects female infants and is lethal in the majority of males during fetal life. The clinical findings include skin lesions, developmental defects, and defects of the eyes, teeth, skeletal system, and central nervous system. Cardiovascular complications of thi...

IP: incontinentia pigmenti NFkB: nuclear factor kB TNF: tumor necrosis factor INTRODUCTION Incontinentia pigmenti (IP; Bloch-Sulzberger syndrome) is an X-linked dominant genodermatosis that can have several cutaneous, dental, skeletal, neurologic, and ocular manifestations, including retinal detachment, seizures, paralysis, developmental delay, hair loss, and abnormal dentition. Lethal for affe...

EDITOR Dr. Rosen graduated from the University of Michigan Medical School, then trained in internal medicine at the University of Alabama, and in dermatology at Baylor College of Medicine. He currently serves as Professor of Dermatology at Baylor and Chief of Dermatology at the Houston Veterans Affairs Medical Center. He is active in the American Academy of Dermatology, having served on the Boa...

Occluded sweat ducts are the hallmark of miliaria. The occlusions were thought to be due to biofilm or “slime” producing Staphylococcus epidermidis. Sulzberger first saw occluded ducts in eczema and 60 years later, these were rediscovered and shown to be due to many different species of staphylococci, including S. aureus, epidermidis, tenuis and many others. These occlusions also trigger the ac...

Incontinentia pigmenti is a rare X-linked genodermatosis that affects mainly female neonates. Skin manifestations are the most common and occur in four quite distinct phases. A female infant presented vesiculobullous lesions on trunk and limbs, and a verrucous lesion on the right palm. Biopsy revealed eosinophil exocytosis and pigment incontinence, confirming the clinical hypothesis. Although u...

Case presentation of staged surgical treatment of patients with spinal deformity in incontinentia pigmenti syndrome. As a result of surgical procedure proper sagittal balance of the body was restored.

We describe a means for constructing phishing experiments which achieve the mutually competitive goals of being ethical and accurate. We present an implementation of these experiments based on the user interface of a popular online auction site, and the results gained from performing these experiments on several hundred subjects. In particular, we find that cousin domains (such as ebay.secure-n...

Traditional “traceability” (the flipside idea to “anonymity”) on the Internet attempts to identify the IP address that caused an action to occur. This is sufficient for an Internet Service Provider (ISP) to take action against the authorized user of that IP address. Law enforcement agencies usually need to go beyond this in order to identify the individual concerned. However, shared accounts, u...