نتایج جستجو برای: sumatriptan succinate
تعداد نتایج: 8638 فیلتر نتایج به سال:
benefit offered by sumatriptan therapy? Cephalalgia 1995; 15(suppl 14):263 12 Fowler PA, Lacey LF, Thomas M, Keene ON, Tanner RJN, Baber NS. The clinical pharmacology, pharmacokinetics and metabolism of sumatriptan. Eur Neurol 1991; 31:291-4. 13 Blau JN. Sumatriptan and the recurrence of migraine. Lancet 1992;340: 1110. 14 Mathew NT. Drug-induced headache. Neurol Clin 1990; 8:903-12. 15 Mathew ...
Objectives: The objective was to evaluate the seizure provoking effect of sumatriptan, and its abolition with fluoxetine in the pentylenetetrazolinduced seizures in rats. Methods: 100 Sprague-Dawley rats of either sex were randomized into 10 groups with each group consisting 10 rats. The first group was taken as a control group which received distilled water. The second group and the third grou...
Lithium is a drug used for the treatment of bipolar disorder. It has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-HT1B/1D serotonin receptors. Sumatriptan is a 5-HT1B/1D receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. In this study, effects of lithium on sumatrip...
igraine causes substantial patient suffering and high costs to managed care organizations and employers. Triptans (5-HT1B/1D receptor agonists) are effective and relatively safe for the acute treatment of migraine. Initial treatment with a triptan is recommended when the migraine is judged moderate to severe or in migraine of any severity when nonsteroidal anti-inflammatory drugs and combinatio...
BACKGROUND Pharmacological studies of the enteric nervous system have shown the presence of several subtypes of 5-hydroxytryptamine (5HT) receptor, which might be involved in control of the migrating motor complex. AIMS To study the effect of sumatriptan, an agonist of enteric neuronal 5HT1p receptors, on interdigestive motility in man. SUBJECTS AND METHODS In 12 healthy subjects, interdige...
Sumatriptan, a novel selective 5-hydroxytryptamine1d (5-HT1d) receptor agonist, which is highly effective in the acute treatment of migraine attacks, blocks dural neurogenic plasma extravasation and constricts cranial blood vessels in animal experiments. We measured intra- and extracranial blood flow velocities (BFV) with a transcranial Doppler device in 67 patients during a spontaneous migrain...
OBJECTIVE To compare the efficacy of oral eletriptan, 40 mg and 80 mg, and oral sumatriptan, 50 mg and 100 mg, in the acute treatment of migraine. METHODS Patients with a history of migraine (n = 1,008) were randomly assigned to receive placebo, 40 mg of eletriptan, 80 mg of eletriptan, 50 mg of sumatriptan, or 100 mg of sumatriptan to treat up to three attacks. Early headache response (at 1 ...
Written instructions and accompanying photographs dealing with self-administration of sumatriptan are available at most pharmacies and are enclosed in the self-dosing kit you will receive with your initial prescription. While preparation of the auto-injector is not particularly difficult, it is a good idea to familiarize yourself with its use during a quiet time when you are free of headache or...
OBJECTIVE To compare the efficacy of ketorolac nasal spray (NS) vs. placebo and sumatriptan NS for the acute treatment of migraine. METHODS This was a randomized, double-blind, placebo and active-comparator, crossover study. Adult migraineurs were randomized to ketorolac NS 31.5 mg, sumatriptan NS 20 mg, or placebo to treat three moderate to severe migraine attacks and switched treatments wit...
migraine is a common and incapacitating neurologic disorder manifesting with episodic moderate to a severe headache and other symptoms such as photophobia, phonophobia, nausea, and vomiting. triptans and ergot compounds have been used as treatment options for an acute migraine headache for many years. triptans are considered the first line of treatment in patients with moderate to a severe migr...
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