Abstract Background Cilnidipine, a calcium channel blocker, is the first-line drug for hypertension and belongs to Biopharmaceutics Classification System II. To mitigate its extensive first-pass metabolism improve patient compliance, present study was performed develop characterize solid dispersion-based orodispersible tablets. Results The phase solubility with polyvinyl pyrrolidone 15% has sho...

Aim: This work aims to develop oral disintegrating tablets from solid dispersion of aripiprazole that are capable enhancing solubility.
 Methodology: Aripiprazole an antipsychotic is a BCS class IV drug with Oral bioavailability 87%. To enhance the solubility this dispersions were prepared by using combination ?-Cyclodextrin and PVP K30 in 1:1, 1:2 physical mixture solvent evaporation meth...

Migraine, a neurological condition is often associated with intense, throbbing, crippling headaches for hours to days. Rizatriptan benzoate has established its potential in controlling the symptoms of migraine. The present study aims formulate bilayer tablet rizatriptan multi release unit matrix embedded sustained layer achieve pulsatile drug control various phases A preliminary on four matrice...

Background: Modafinil is a CNS stimulant used to treat Narcolepsy, sleepiness and other disorders related sleep. It BCS class II drug having poor aqueous solubility.
 Objective: This study was aimed formulate evaluate orodispersible tablets of containing co-crystals for the improvisation critical attributes product such as dissolution rates, solubility oral bioavailability.
 Methods: ...

Background: The main objective of present research work is to formulate the Carbamazepine as Fast Disintegrating tablets give fast relief and an increase in patient compliance. Carbamazepine, antiepileptic, belongs BCS Class-II used control some types seizures treatment epilepsy Neuropathic Pain by blocking use-dependent sodium channels.
 Methods: powdered materials were compressed direct ...

The influence of excipients on the disintegration times of tablets and the release of papaverine hydrochloride (PAP) from tablets were studied. Ten different formulations of tablets with PAP were prepared by direct powder compression. Different binders, disintegrants, fillers, and lubricants were used as excipients. The release of PAP was carried out in the paddle apparatus using 0.1 N HCl as a...