Superficial siderosis of the central nervous system results from hemosiderin deposition in the subpial layers of the brain and spinal cord. A clinical history of subarachnoid hemorrhage is often absent. Patients present with slowly progressive gait ataxia and sensorineural hearing impairment. A history of prior intradural surgery or trauma is common. With widespread use of magnetic resonance im...

Superficial siderosis of the central nervous system is a very uncommon disorder. We report a rare case of spinal ependymoma in a 58-year-old man whose main complaints at presentation were recent lumbago and headache, and he was evaluated to confirm suspected spinal subarachnoid hemorrhage (SAH). After cerebrospinal fluid analysis and imaging studies the patient was diagnosed with SAH and superf...

rhages with superficial siderosis. J Neurol Neurosurg Psychiatry. 2009;75:1463—6. 5. Mascalchi M, Salvi F, Pirini MG, D’Errico A, Ferlini A, Lolli F, et al. Thranstyretin amyloidosis and superficial siderosis of the CNS. Neurology. 1999;53:1498—502. 6. Benson MD, Smith RA, Hung G, Kluve-Beckerman B, Showalter AD, Sloop KW, et al. Suppression of choroid plexus transthyretin levels by antisense o...

With great interest, we read the recent review article by Kumar entitled “Neuroimaging in Superficial Siderosis: An In-Depth Look,” published on-line ahead of print in the American Journal of Neuroradiology in September 2009. The author provides a thorough review of neuroimaging in superficial siderosis (SS) of the central nervous system and details important underlying causes of this phenomeno...

See related article, pages 2894–2897. In this issue of Stroke, Feldman and coworkers1 describe 3 subjects with clinically somewhat atypical Alzheimer Disease (AD) and with a radiologically verified superficial siderosis (SS). In 2 of these patients, a neuropathological examination confirmed AD with concomitant cerebral amyloid angiopathy (CAA) and a premortem diagnosis of SS. Thus, a linkage wa...