Specific tolerance to phosphorylcholine (PC) can be induced in BALB/c mice by neonatal injection with either pneumococcal C-polysaccharide (PnC) or anti-TEPC 15 idiotype (T15Id) antibody specific for the major idiotype (Id) of anti-PC antibody. Spleen cells from these tolerant mice exhibited T cell-mediated active suppression of anti-PC response when they were co-cultured with normal spleen cel...

Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC−/− showed elevated cytokines with severer pathology, reduced body weight, earlier death. Reversal of colitis symptoms by IL-22 antagonism suggests the existence MSC:IL-22 regulatory axis.

The present study was undertaken to identify tumor vaccineinduced suppressor cells and to examine the effect of antineoplastic agents on their production and suppressor activity. Primary and secondary sensitization with concanavalin A (Con A)-bound L1210 murine leukemia cell vaccine induced sup pressor cells in the peritoneal cavity of histocompatible BALB/ c X DBA/2Cr F! mice. These cells phag...

Suppressor cell activity for in vitro gamma interferon (IFNgamma) production can be induced in C57BL/6 mice with the T-cell mitogens staphylococcal enterotoxin A and concanavalin A. The suppressor cell lacked mitogen specificity in that injection of mice with either staphylococcal enterotoxin A or concanavalin A induced potent suppressor cell activity that inhibited the in vitro induction of IF...

Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation progression of cancer. The purpose this study was to retrospectively investigate expression mitochondrial tumor-suppressor DNA-repair proteins in patients oral squamous cell carcinoma (OSCC) evaluate relationship between their prognosis. We enrolled 197 OSCC who underwent surgical re...