introduction: ciprofloxacin which was used in this study is a fluoroquinolone (fq). this kind of drug may cause epileptic seizures probably because of the inhibition of gaba binding to its receptors. wag/rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. methods: for eeg study, electrodes were inserted into the cortex of animals according to paxinos...

Although minutes of a spinning episode may induce vertigo in the healthy human, as a result of a possible perceptional plasticity, Sufi Whirling Dervishes (SWDs) can spin continuously for an hour without a vertigo perception.This unique long term vestibular system stimulation presents a potential human model to clarify the cortical networks underlying the resistance against vertigo. This study,...

Sodium valproate(VPA), ethosuximide(ESM), 200 mg/kg ip and flunarizine (FLU) 5 or 10 mg/kg ip were first administered independently to rats in order to study their effects on behavioural and EEG aspects of spike and wave discharges (SWDs) induced by y- hydroxybutyrate (GHB,100 mg/kg ip). GHB treated rats show behavioural changes and concomitant repetitive EEG episodes of 7 to 9 Hz SWDs, mimicki...

Absence seizures are the most pure form of generalized epilepsy. They are characterized in the electroencephalogram by widespread bilaterally synchronous spike-wave discharges (SWDs), which are the reflections of highly synchronized oscillations in thalamocortical networks. To reveal network mechanisms responsible for the initiation and generalization of the discharges, we studied the interrela...

Absence seizures consist of bilateral spike-and-wave discharges (SWDs) occurring over widespread cortical and thalamic regions. In genetic models of absence epilepsy, recent in vivo investigations indicate that SWDs emerge first in the facial somatosensory cortex and then propagate via the corticothalamocortical loop. The specific involvement of this cortical region in ictogenic processes remai...

Objective: In the last two decades, research on epigenetic mechanisms has expanded dramatically. Recent studies demonstrated that regulate epilepsy and epileptogenic pathologies. this study, we aimed to investigate changes in promoter methylation status of voltage-gated T-type calcium channel alpha 1 subunit G (CACNA1G) gene total histone deacetylase activity Wistar Albino Glaxo/Rijswijk (WAG/R...

Absence seizures consist of a brief and sudden impairment of consciousness. They are characterized by bilaterally synchronized spike and wave discharges (SWDs), which reflect abnormal oscillations in the thalamocortical loops. Recent studies have suggested that the basal ganglia are involved in generation of the SWDs, but their roles are poorly understood at the molecular and cellular levels. H...

Employment is one important post-school outcome for youth and adults its benefits include enjoying a productive life, enhanced self-worth, economic independence. Although Botswana has made notable strides to enhance outcomes students with disabilities (SWDs), many of these continue face underemployment unemployment. Hence, this study used quantitative research approach examine vocational teache...

With the fast growth of the Internet, more and more information is available on the Web. The Semantic Web has many features which cannot be handled by using the traditional search engines. It extracts metadata for each discovered Web documents in RDF or OWL formats, and computes relations between documents. We proposed a hybrid indexing and ranking technique for the Semantic Web which finds rel...

The purpose of this paper is to support the development of so-called good practice guidelines for the estimation of methane (CH4) emissions from solid waste (SW) disposal for national greenhouse gas inventories. The paper reviews and discusses the emission estimation methods given in the IPCC 1996 Revised Guidelines (IPCC Guidelines), and uncertainty and quality management issues related to the...