The Swedish mutation (K595N/M596L) of amyloid precursor protein (APP-swe) has been known to increase abnormal cleavage of cellular APP by Beta-secretase (BACE), which causes tau protein hyperphosphorylation and early-onset Alzheimer's disease (AD). Here, we analyzed the effect of APP-swe in global gene expression using deep transcriptome sequencing technique. We found 283 genes were down-regula...

The knowledge of snow storage plays a fundamental role for many reasons. For example, in many regions of the world the majority of total annual precipitation occurs as snowfall and melting snow represents a major source of fresh water. Improved estimates of snow storage will benefit regional-scale hydrological models and general circulation models (GCMs) and will lead to better simulations of l...

Since 2002, global snow water equivalent (SWE) estimates have been generated using Advanced Microwave Scanning Radiometer (AMSR-E)/Aqua data. Accurate estimates of SWE are important to improve monitoring and managing of water resources in specific regions. SWE and snow map product accuracy are functions of topography and of land cover type because landscape characteristics have a strong influen...

The aim of the present study was to evaluate the value of shear wave elastography (SWE) and contrast-enhanced ultrasonography (CEUS) in the diagnosis of thyroid malignant nodules. A total of 253 patients with 319 thyroid nodules were subjected to two-dimensional ultrasound (2DUS) and CEUS examinations prior to thyroidectomy between March, 2014 and December, 2015. Young's modulus value for each ...

AIM To evaluate the usefulness of three-dimensional (3D) shear-wave elastography (SWE) in assessing the liver ablation volume after radiofrequency (RF) ablation. METHODS RF ablation was performed in vivo in 10 rat livers using a 15-gauge expandable RF needle. 3D SWE as well as B-mode ultrasound (US) were performed 15 min after ablation. The acquired 3D volume data were rendered as multislice ...

Lipid-laden peripheral tissue cells release cholesterol to an extracellular acceptor such as high-density lipoprotein (HDL). Foam cells are formed at the first stage of atherosclerosis development. This study investigated whether sage weed (Salvia plebeia) extract (SWE) influences cholesterol handling of J774A1 murine macrophages. A murine macrophage cell line, J774A1, was used in this study. O...

The National Weather Service’s Snow Data Assimilation (SNODAS) program provides daily, gridded estimates of snow depth, snow water equivalent (SWE), and related snow parameters at a 1-km resolution for the conterminous USA. In this study, SNODAS snow depth and SWE estimates were compared with independent, ground-based snow survey data in the Colorado Rocky Mountains to assess SNODAS accuracy at...

Subcritical water extraction (SWE) is an alternative technique that implement water as a solvent. The objective of this work was to compare the efficiency of SWE in temperature range from 100ºC to 180ºC at extraction times ranging from 5 to 25 minutes with an ethanolic soxhlet extraction in terms of total phenolic content (TPC), total flavonoid content (TFC) and radical scavenging activity (RSA...

KUČEROVÁ, D., JENÍČEK, M. (2014): Comparison of selected methods used for the calculation of the snowpack spatial distribution, Bystřice River basin, Czechia. Geografie, 119, No. 3, pp. 199–217. – The knowledge of the water volume stored in the snowpack, including its spatial distribution, is vital for many hydrological applications. Such information is useful for hydrological forecasts and it ...