Hypertension is a serious risk factor for various diseases. Therefore, lowering and preventing high blood pressure significant issue. Blockage of the renin-angiotensin-aldosterone system (RAAS), which controls pressure, important to reduce consequently symptoms heart failure. This blockage can be carried out by angiotensin-converting enzyme (ACE) angiotensin II receptor blockers (ARBs). The phe...

Centella asiatica is a traditional natural medicine used in number of Southeast Asian nations. (also known as L., Urb., or Gotu Kola). The aim this study to determine the antihyperuricemia properties extract and possibility that they will interact with XDH enzyme. enzyme one three enzymes can influence onset hyperuricemia other two are SLC22A12 ABCG2. In research, we employ computational method...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzyme defect in humans, caused by a mutation X-linked gene encoding G6PD. The G6PD plays an important role to produced reducing agents which maintain reduced glutathione through pentose phosphate pathway. On ingestion of Faba Bean (Vicia faba L.), vicine and convicine are hydrolyzed β -glucosidase divicine isoura...

Docking has been used currently in the early development of a drug candidate and useful tool to predict absorption, distribution, metabolism, excretion (ADME) properties. Lycopene shows strongest antioxidant activity among carotenoids, anticancer activity. This study predicts ADME simulates docking lycopene binding B-celllymphoma 2 (Bcl2) DNA (cytosine-5)-methyltransferase 1 (DNMT1) proteins ca...

Specific sidechain modifications on the indole-benzimidazole scaffold play fundamental roles for determining molecule's affinity against ER? and its anti-cancer activity.

New pyridine derivatives of nabumetone containing 2-amino 3-cyano moieties were synthesized and aimed to introduce new EGFR kinase inhibitors through two methods either by synthesis chalcone initially (1a-d)
 followed reacting it with malononitrile ammonium acetate form (2a-d) or from a one-pot all reactants together compounds (2a-e). Melting point, FT-IR spectra used characterize the conf...

The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis. The potassium channel opening effects of the compounds were determined o...

BACKGROUND Obesity is a progressive metabolic disorder in the current world population, and is characterized by the excess deposition of fat in the adipose tissue. Pancreatic lipase is one of the key enzymes in the hydrolysis of triglycerides into monoglycerides and free fatty acids, and is thus considered a promising target for the treatment of obesity. The present drugs used for treating obes...

Objective: In this study, it was aimed to carry out computational studies for the development of new molecules inhibition cyclophilin D (CypD) receptor, which causes disability mitochondrial function in multiple sclerosis (MS) disease. Material and Method: Pharmacophore modeling study applied via PharmaGist Web server CypD inhibitors detected by literature search. According best pharmacophore m...

A novel 3,4-dihydroisoquinol-1-one-4-carboxamide scaffold was designed as the basis for development of inhibitors poly(ADP-ribose) polymerase (PARP). Synthesis 3,4-dihydroisoquinol-1-one-4-carboxylic acids achieved using previously developed protocol based on modified Castagnoli-Cushman reaction homophthalic anhydrides and 1,3,5-triazinanes formaldimine synthetic equivalents. Employment 2,4-dim...