نتایج جستجو برای: t cell inhibitor
تعداد نتایج: 2296471 فیلتر نتایج به سال:
Despite advances in immunosuppressive regimens, acute graft-versus-host disease remains a frequent complication of allogeneic hematopoietic cell transplantation. Pathogenic donor T cells are dependent on correct attachment of small GTPases to the cell membrane, mediated by farnesyl- or geranylgeranyl residues, which, therefore, constitute potential targets for graft-versus-host disease prophyla...
In the last decade, immunotherapy led to a paradigm shift in treatment of numerous malignancies. Alongside with monoclonal antibodies blocking programmed cell death receptor-1 (PD-1)/PD-L1 and cytotoxic T- lymphocyte antigen 4 (CTLA-4) immune checkpoints, cell-based approaches such as CAR-T cells dendritic (DC) vaccines have strongly contributed pushing forward this thrilling field. While initi...
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