This study investigated the effects of alcoholic extract of Butea superba (BS) on cognitive deficits and depression-related behavior using olfactory bulbectomized (OBX) mice and the underlying molecular mechanisms of its actions. OBX mice were treated daily with BS (100 and 300 mg/kg, p.o.) or reference drugs, tacrine (2.5 mg/kg, i.p.) and imipramine (10 mg/kg, i.p.) from day 3 after OBX. OBX i...

Our previous reports indicated that bis(propyl)-cognitin (B3C) and bis(heptyl)-cognitin (B7C), as novel dimers derived from tacrine, may be potential multifunctional drugs for treating Alzheimer's disease. There is little knowledge on the cognitive function of B3C while B7C appeared to reverse learning and memory impairments. In this study, for the first time, we evaluated the anti-amnesic effe...

Acanthopanax trifoliatus is a plant that has been traditionally used in Thailand as a vegetable and a tonic. This study investigated effects of the aqueous extract of its leaves (ATL) on cognitive and emotional deficits using an olfactory bulbectomized mouse (OBX) model. OBX mice were treated daily with ATL (250 and 500 mg/kg, p.o.) 3 days after OBX. Antidementia drug tacrine (2.5 mg/kg/day) an...

Tacrine and suxamethonium were used to produce muscle relaxation in 29 anaesthetized patients. Relaxation was monitored with a nerve stimulator. Post-tetanic facilitation was observed in 24 patients (83 per cent). In spite of this, operating conditions were satisfactory in 26 patients. Poor operating conditions were associated with the more severe degrees of phase II block as judged by an incre...

The aim of the work was to establish spect­rum biological activity new derivatives 9-bromo-1,2,3,4-tetrahydroacridine due limi­ted amount literature data. In silico prediction selected bromo-derivatives hydrogenated acridines performed using SuperPred 3.0 web resource. obtained results were compared with active drugs that contain acridine cycle in their structure - Tacrine, Amiridine and Amsacr...

Alzheimer’s disease (AD) as a complicated and progressive neurodegenerative disorder is the most common form of dementia and memory loss. On account of the multifactorial etiology of AD, the multi-target-directed ligand (MTDL) approach is a promising method in searching new drug candidates for this disease. Here, in this paper more than 500 tacrine-coumarin hybrids have been designed and drug-l...

Alzheimer’s disease (AD) as a complicated and progressive neurodegenerative disorder is the most common form of dementia and memory loss. On account of the multifactorial etiology of AD, the multi-target-directed ligand (MTDL) approach is a promising method in searching new drug candidates for this disease. Here, in this paper more than 500 tacrine-coumarin hybrids have been designed and drug-l...

Abstract: Background: Parkinson’s disease is neurodegenerative with no cure till now, there are treatments that can be explored to ease the symptoms of this disease, and using plant extract we explore possibility neutralizing adverse providing better quality life patients. Purpose: To demonstrate Anti-parkinson’s activity Phaseolus vulgaris methanol pod by behavioural models in Wister Albino ra...

Tacrine is a classic drug whose efficacy against neurodegenerative diseases still shrouded in mystery. It seems that besides its inhibitory effect on cholinesterases, the clinical benefit co-determined by NMDAR-antagonizing activity. Our previous data showed direct of tacrine, as well 7-methoxy derivative (7-MEOTA), ensured via “foot-in-the-door” open-channel blockage, and interestingly both ta...