نتایج جستجو برای: tap
تعداد نتایج: 12168 فیلتر نتایج به سال:
Newly assembled heavy chain-beta 2m heterodimers of class I histocompatibility molecules associate with the endoplasmic reticulum (ER) peptide transporter, TAP, and subsequently dissociate from TAP in parallel with their transport from the ER to the Golgi apparatus. It appears that TAP-associated class I molecules are waiting to bind appropriate peptides before they dissociate from TAP and leav...
Tap has been proposed to play a role in general mRNA export and also functions in expression of RNA with retained introns that contain the MPMV CTE (constitutive transport element). Tap forms a functional heterodimer with NXT/p15. We have previously demonstrated that unspliced intron-containing CTE RNA is efficiently exported to the cytoplasm in mammalian cells. Here we show that Tap and NXT pr...
The mammalian protein TAP/p115 and its yeast homologue Uso1p have an essential role in membrane traffic (Nakajima et al., 1991; Waters et al., 1992; Sztul et al., 1993; Rabouille et al.; 1995). To inquire into the site and mechanism of TAP/p115 action, we aimed to localize it and to identify domains required for its function. We show that in interphase cells, TAP/p115 localizes predominantly to...
Epidemiologic studies suggested that vitamin E has a protective effect against prostate cancer. We showed here that tocopherol-associated protein (TAP), a vitamin E-binding protein, promoted vitamin E uptake and facilitated vitamin E antiproliferation effect in prostate cancer cells. Interestingly, without vitamin E treatment, overexpression of TAP in prostate cancer cells significantly suppres...
We present what we believe to be the first formal verification of a biologically realistic (nonlinear ODE) model of a neural circuit in a multicellular organism: Tap Withdrawal (TW) in C. Elegans, the common roundworm. TW is a reflexive behavior exhibited by C. Elegans in response to vibrating the surface on which it is moving; the neural circuit underlying this response is the subject of this ...
Accurate temporal information processing is critically important in many motor activities within disciplines such as dance, music, and sport. However, it is still unclear how temporal information related to biological motion is processed by expert and non-expert performers. It is well-known that the auditory modality dominates the visual modality in processing temporal information of simple sti...
BACKGROUND The transporter associated with antigen processing (TAP) supplies cytosolic peptides into the endoplasmic reticulum for binding to major histocompatibility complex (MHC) class I molecules. Its specificity therefore influences the repertoire of peptides presented by MHC molecules. Compared to human TAP, murine TAP's binding specificity has not been characterized as well, even though m...
تحقیق حاضر به بررسی چگونگی تاثیر تکنیک های مبتنی بر شرح معنایی، شرح ساختاری و شرح معنایی-ساختاری در روند یادگیری لغات پرداخته است. براساس مدل topra فرض گردید که شرح معنایی-ساختاری در مقایسه با شرح معنایی و شرح ساختاری تاثیر منفی در روند یادگیری لغات خواهد داشت. بر اساس مدل lop فرض بر این بود که شرح معنایی در مقایسه با شرح ساختاری منجر به افزایش میزان یادگیری لغات خواهد شد. علاوه بر این در حالت ...
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