نتایج جستجو برای: taxane
تعداد نتایج: 2009 فیلتر نتایج به سال:
BACKGROUND Capecitabine is effective and indicated for the salvage treatment of metastatic breast cancer. Therefore, it is essential to evaluate the efficacy of capecitabine in the adjuvant setting. There have been two large randomized studies to determine whether patients with high-risk early breast cancer benefit from the addition of capecitabine to standard chemotherapy, but they have yielde...
Prostate cancer (PCa) is associated with chronic prostate inflammation resulting in activation of stress and pro-survival pathways that contribute to disease progression and chemoresistance. The stress oncoprotein lens epithelium-derived growth factor p75 (LEDGF/p75), also known as DFS70 autoantigen, promotes cellular survival against environmental stressors, including oxidative stress, radiati...
PURPOSE A field study of postchemotherapy immune functioning relative to the use of taxanes is reported. Immune responses in breast cancer patients were analyzed as a function of whether patients received taxane as part of their adjuvant chemotherapy. EXPERIMENTAL DESIGN Immune levels of 227 stage II/III breast cancer patients were measured immediately after surgery prior to chemotherapy and ...
mainstay of treatment for patients with breast cancer and lung cancer, and also patients with metastatic prostate cancer sometimes undergo taxane chemotherapy. Taxanes may also act as radiation enhancers. Paclitaxel interferes with the mitotic spindle function by enhancing the rate and yield of microtubule assembly and preventing microtubule polymerization. This interference results in the arre...
PURPOSE Polo-like kinase 4(PLK4) is an important evolutionarily regulator involved in centrosome duplication. We here investigated the expression of PLK4 mRNA and PLK4 in breast cancer, and evaluated its predictive value for response to taxane-based neoadjuvant chemotherapy. METHOD The PLK4 mRNA expression was measured in breast cancer tissues and corresponding normal breast tissues from 30 b...
BACKGROUND Few options are available after taxane-based therapy in men with CRPC. Genetic alterations involving the mTOR pathway have been associated with CRPC development, raising the hypothesis that blocking mTOR signaling may be an effective targeted approach to treatment. PATIENTS AND METHODS In this open-label phase II study, the mTOR inhibitor Ridaforolimus was administered at a dose of...
Mitosis is the most conspicuous cell cycle phase and Shugoshin-like 1 (SGOL1) is a key protein in protecting sister chromatids from precocious separation during mitosis. We studied the role of SGOL1 and its splice variants in non-small cell lung cancer (NSCLC) using 82 frozen NSCLC tissue samples. SGOL1-B expression was prevalent in smokers, in cases with a wild-type (WT) EGFR status, and in ca...
AIM Recent clinical, randomized and observational studies showed that eribulin, an analogous of Halichondrin B, was beneficial and well-tolerated in heavily pretreated metastatic breast cancer patients. Here, we aim to evaluate the effectiveness and safety of eribulin in taxane-refractory metastatic breast cancer patients. PATIENTS & METHODS In this subanalysis of the ESEMPIO study database, ...
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