Multiple endocrine neoplasia type 1 (MEN1 or Wermer syndrome) is a rare hereditary disease, and especially its association with ectopic parathyroid adenomas even more. Defined As tumor developing in at least two glands including the anterior pituitary gland, duodeno-pancreatic tissue. This autosomal dominant pathology caused by mutation of NEM1 gene encoding suppressor menin located on chromoso...

The purpose of this study was to validate whether dipyridamole stress ultrasonic tissue characterization with cyclic variation of integrated backscatter (CVIBS) compared with dipyridamole stress echocardiography and dipyridamole stress Tc99m-MIBI SPECT myocardial perfusion scintigraphy could predict myocardial ischemia in patients with chronic coronary artery disease. Twenty patients (16 M, 4 F...

UNLABELLED Our objective was to investigate the feasibility of subtraction for SPECT images of (99m)Tc-MIBI double-phase parathyroid scintigraphy. METHODS Fourteen patients with hyperparathyroidism were enrolled in the present study. Histopathologically, excised tissue specimens showed hyperplasia in 11 patients and adenoma in 3 patients. Both ultrasonography and (99m)Tc-sestamibi (MIBI) SPEC...

Primary hyperparathyroidism caused by parathyroid adenoma requires surgical resection. To confine the extent of surgery to very minimum and exclude an atypical location, preoperative imaging aims at identifying suspicious gland. For this purpose, Technetium-99m (99mTc)-sestamibi scintigraphy SPECT have become international standard, in inconclusive cases also with C-11 methionine F-18 choline P...

PURPOSE The role of preoperative localization studies is controversial in surgery of secondary hyperparathyroidism (sHPT). The aim of study was to evaluate the accuracy of preoperative ultrasonography (USG), CT, and (99m)Tc sestamibi scintigraphy (MIBI) in localizing enlarged parathyroid glands and to find the impact of correct localization in successful parathyroidectomy. METHODS We compared...

Background Selective venous sampling (SVS) is an invasive localization study for persistent or recurrent hyperparathyroidism. Purpose To assess the role of SVS in addition to non-invasive imaging for primary hyperparathyroidism (pHPT). Material and Methods This study was approved by the institutional review board and included 14 patients who underwent SVS and subsequent parathyroidectomy be...

A common cause for surgical failure of primary hyperparathyroidism (pHPT) is the non-detection of an ectopic adenoma during the intervention. We present a case of a patient with pHPT in whom an ectopic gland was found in the right retropharyngeal space by means of a double phase (99m)Tc-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) scintigraphy and early SPECT-CT after several surgeries and imagin...

BACKGROUND Investigations using a hybrid single photon emission computed tomography/computed tomography (SPECT-CT) scanning technique have been carried out in limited studies and have shown mixed results. However, the assessment of this technique for the detection of parathyroid adenoma in patients with a nodular goiter was performed in only one study with a small sample size. The aim of this p...

We report here a rare case of primary hyperparathyroidism that was associated with an ectopic parathyroid adenoma located in the mediastinum. A 66-year-old woman suffering from primary hyperparathyroidism had been followed-up on an outpatient basis for over 10 years. She suffered from persistent urolithiasis and osteopenia due to hypercalcemia. After technetium-99-sestamibi (99mTc-MIBI) scintig...