We report a patient with fetal hydantoin syndrome and hypoplastic left heart. Only three other cases with this association have been described. This case also highlights the importance genetic variation plays in the phenotypic variability of teratogens and the importance of good prenatal care to minimize risk of teratogenesis.

in studies on teratogenesis. Fetuses afflicted with holoprosencephaly, including varying degrees of such malformations as pituitary agenesis, cyclocephaly, cyclopia and monorhinia, can be obtained by administering triparanol or AY 9944 which inhibits cholesterol synthesis. A large number of fetuses have a minor form of holoprosencephaly, i.e. limited to isolated hypophyseal agenesis. We used th...

Treacher Collins syndrome: abnormal first branchial arch development giving rise to malar and mandibular hypoplasia with external ear malformations. Dysmorphology is the study of malformations arising from abnormal embryogenesis. Recognition of patterns of multiple congenital malformations may allow inferences to be made about the timing, mechanism, and aetiology of structural defects. Animal r...

In biomedical scientific investigations, expositions of findings are conceptually simplest when they comprise comparisons of discrete groups of individuals or involve discrete features or characteristics of individuals. But the descriptive benefits of categorization become outweighed by their limitations in studies involving dose-response relationships, as in many teratogenic and environmental ...