We wanted to evaluate the effect of terfenadine, a selective H1-receptor antagonist, on alcoholic beverage-induced bronchoconstriction. Eight patients with alcohol-induced asthma received terfenadine (60 mg, twice on the test day) or placebo, with the last dosing 2 h before the test in a double-blind, randomized, cross-over manner. On two separate study days, each subject drank the same brand a...

BACKGROUND Defective protein trafficking is a consequence of gene mutations. Human long-QT (LQT) syndrome results from mutations in several genes, including the human ether-a-go-go-related gene (HERG), which encodes a delayed rectifier K(+) current. Trafficking-defective mutant HERG protein is a mechanism for reduced delayed rectifier K(+) current in LQT2, and high-affinity HERG channel-blockin...

This article evaluates a novel approach for estimating the pharmacokinetic risks associated with drug interactions in populations. Preclinical pharmacokinetic and metabolism data are analyzed with a stochastic differential equation-based pharmacokinetic model that recognizes that the risks associated with known drug interactions involve deterministic and stochastic components. Specifically, a B...

A double-blind clinical trial in 60 patients with perennial rhinitis was conducted to compare the efficacy and side effects of two antihistamines, terfenadine and chlorpheniramine maleate, and placebo. There was no statistically significant difference in response between active treatments and placebo. Although side effects were more frequent with chlorpheniramine this also was not statistically...

DEPUIS LA MISE EN VENTE DE LA TERFÉNADINE, antihistaminique non sédatif, il y a plus de 20 ans, des rapports sur des cas d’arythmie cardiaque et de mort subite associée à son utilisation ont entraîné son retrait du marché dans certains pays. Néanmoins, la terfénadine est toujours en vente au Canada. Les avantages qu’offre ce médicament pour contrôler les symptômes de la fièvre des foins ne l’em...

The course has been suggestive ofa hypersensitivity reaction with a shorter period to development ofabnormal liver function after re-exposure to the drug. Ours is the first case with typical pathological features of chronic active hepatitis. The evidence strongly implicated cimetidine. Inadvertent re-exposure to the drug caused rapid recurrence of jaundice and abnormal liver function values, an...