objective(s)previous studies have shown that vitamin b as well as folate supplementation has been implicated in cognitive and neurodegenerative disorders including alzheimer’s and parkinson's diseases. the aim of present study was to evaluate the effects of folic acid on passive avoidance task and motor coordination in healthy adult male rats.materials and methodsanimals were randomly divi...

Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sl...

The present study focuses on the functional interactions of cognition and manual action control. Particularly, we investigated the neurophysiological correlates of the dual-task costs of a manual-motor task (requiring grasping an object, holding it, and subsequently placing it on a target) for working memory (WM) domains (verbal and visuospatial) and processes (encoding and retrieval). Thirty p...

Previous research suggested that working memory (WM) does not play any significant role in visual search. In three experiments, we investigated the search difficulty and individual differences in WM capacity as determinants of WM involvement during visual search tasks, using both behavioral and electrophysiological markers [i.e., the contralateral delay activity (CDA), which is a marker for WM ...

We describe and evaluate a recall reconstruction hypothesis for working memory (WM), according to which items can be recovered from multiple memory representations. Across four experiments, participants recalled memoranda that were either integrated with or independent of the sentence content. We found consistently longer pauses accompanying the correct recall of integrated compared with indepe...

Detailed computational modeling of human memory has typically been aimed at either short-term (working) memory or long-term memory in isolation. However, recent research highlights the importance of interactions between these systems for both item and order information. At the same time, computational models of both systems are beginning to converge onto a common framework in which items are as...

Previous studies have shown that working memory (WM) plays an important role in selective attention, sothat high WM load leads to inefficient distractor inhibition, in comparison with low WM load. In the present study, we examined the effect of WM on distractor processing while the extent of attentional focus was held constant. Our results show that WM load affected distractor processing only w...

Dual-task costs depend on the specific pairings of stimulus and response modalities. Such findings are analogous to domain-specific effects in the working memory (WM) literature, in which items compete for limited capacity when they involve related types of information. The present study explicitly examines the relationship between modality-pairing effects on dual-task costs and domain-specific...

Substantial evidence suggests that individual differences in estimates of working memory capacity reflect differences in how effectively people use their intrinsic storage capacity. This suggests that estimated capacity could be increased by instructions that encourage more effective encoding strategies. The present study tested this by giving different participants explicit strategy instructio...