Delta(9)-Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, CB(1) and CB(2) receptors. CB(1) receptors have been detected on enteric nerves, and pharmacological effects of their activation include gastroprotection, reduction of gastric and intestinal motili...

We have applied sweeping micellar electrokinetic chromatography (sweeping-MEKC) to the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC) and its major metabolites, 11-hydroxy-Delta(9)-tetrahydrocannabinol (THC-OH) and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH). We monitored the effects of several of the sweeping-MEKC parameters, including the proportion of organic...

Purpose: In Korea, it is predicted that the proportion of drug abusers among patients visiting emergency room will soon increase. Several medical institutions in Korea are conducting field urine screening tests for poisoning. this study, we investigated characteristics and usefulness toxicology tests. Methods: The records with positive results tetrahydrocannabinol methamphetamine from at a tert...

The cultivation of hemp was prohibited due to its high content the psychoactive substance Δ-9 tetrahydrocannabinol (THC). Regulatory changes from several countries allow that permits plants and plant parts with less than 0.3% THC. concern levels THC still remains; therefore, testing seed cake (HSC) contributes new information about effect this ingredient on livestock. objective study eval...

The very important psychoactive phytocannabinoid from Cannabis Δ9 tetrahydrocannabinol (Δ9-THC) and its non-psychotropic member is cannabidiol (CBD). These compounds have a variety of pharmacological activities. THC has been approved for the treatment nausea caused by chemotherapy, multiple sclerosis chronic neuropathic pain research underway to use it treat stimulation dementia, anorexia nervo...

Other than the potentially therapeutic bronchodilatory influences of marihuana, very little is known of its biologic effects on the lung. To evaluate this problem, alveolar macrophages were harvested from rats by bronchopulmonary lavage and incubated in vitro with Staphylococcus albus and marihuana smoke of standardized 2.2-percent tetrahydrocannabinol content in graded amounts. After three hou...

Delta9-tetrahydrocannabinol in doses of 0.5, 1.0, 2.0 and 4.0 mg/kg was administered to rats under normal (1 ATA) and increased (3, 5 and 7 times normal) atmospheric pressure. Behavior was maintained by a food-reinforced differential-reinforcemnet-of-low-rate (DRL) schedule. Dose-dependent decrements in performance was observed at the 1 ATA conditions, in which response rates increased and the ...