نتایج جستجو برای: tetrahydropyrimidine

تعداد نتایج: 177  

Journal: :Acta Crystallographica Section E Structure Reports Online 2009

Journal: :Acta Crystallographica Section E Structure Reports Online 2009

2012
M. Mansouri A. Movahedian M. Rostami A. Fassihi

Biginelli-type pyrimidines contain an interesting moiety which has attracted considerable attention of medicinal chemists in the last few decades. Despite the very diverse pharmacologic effects ascribed to this kind of pyrimidines, there are few reports on the antioxidant evaluation of Biginelli pyrimidines. In this study synthesis of some novel Biginelli-type pyrimidines is reported. The prepa...

Journal: :Organic & biomolecular chemistry 2010
Peter R Edwards Jennifer R Hiscock Philip A Gale Mark E Light

The interactions of a series of urea based neutral hydrogen bond donor anion receptors have been investigated with i) alkylcarbamate anions formed by the reaction of carbon dioxide with primary aliphatic amines and ii) the zwitterionic species formed by the reaction of carbon dioxide with 1,4,5,6-tetrahydropyrimidine. Significant downfield chemical shift changes were observed for the urea NH pr...

Journal: :Acta Crystallographica Section E Structure Reports Online 2010

2014
Kerstin Augner Jutta Eichler Wolfgang Utz Monika Pischetsrieder

This study examined the effect of methylglyoxal (MGO)-derived nonenzymatic posttranslational modifications (nePTMs) on the binding affinity of S100A12 to its natural receptor for advanced glycation end-products (RAGE). Binding of MGO-modified S100A12 to RAGE decreased significantly with increasing MGO concentration and incubation time. Ca(2+)-induced S100A12 hexamerization was impaired only at ...

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