نتایج جستجو برای: tgf β receptor 1 tgβri kinase inhibitor

تعداد نتایج: 3452671  

Journal: :Applied sciences 2021

Amelotin (AMTN) is a secretory calcium-binding phosphoprotein controlling the adhesion of epithelial cells to tooth surface, forming protective seal against oral cavity. It can be proposed that signals released upon dentinolysis increase AMTN expression in periodontal cells, thereby helping preserve seal. Support for this assumption comes from our RNA sequencing approach showing gingival fibrob...

2013
Lohith Bachegowda Oleg Gligich Ionnis Mantzaris Carolina Schinke Dale Wyville Tatiana Carrillo Ira Braunschweig Ulrich Steidl Amit Verma

Myelodysplastic syndromes (MDS) are a group of hematologic disorders characterized by ineffective hematopoiesis that results in reduced blood counts. Although MDS can transform into leukemia, most of the morbidity experienced by these patients is due to chronically low blood counts. Conventional cytotoxic agents used to treat MDS have yielded some encouraging results but are characterized by ma...

Journal: :Molecular medicine reports 2015
Rhun Yian Koh Chooi Ling Lim Bruce David Uhal Maha Abdullah Sharmili Vidyadaran Coy Choke Ho Heng Fong Seow

Idiopathic pulmonary fibrosis is a chronic pulmonary disease that is characterized by formation of scar tissue in lungs. Transforming growth factor-β (TGF-β) is considered an important cytokine in the pathogenesis of this disease. Hence, the antifibrotic effect of an inhibitor of the TGF-β type I receptor, namely, SB 431542, was investigated in our study. SB 431542 was used to treat TGF-β-treat...

2017
Yuxiu C Xia Asmaa Radwan Christine R Keenan Shenna Y Langenbach Meina Li Danica Radojicic Sarah L Londrigan Rosa C Gualano Alastair G Stewart

Asthma and chronic obstructive pulmonary disease (COPD) exacerbations are commonly associated with respiratory syncytial virus (RSV), rhinovirus (RV) and influenza A virus (IAV) infection. The ensuing airway inflammation is resistant to the anti-inflammatory actions of glucocorticoids (GCs). Viral infection elicits transforming growth factor-β (TGF-β) activity, a growth factor we have previousl...

1998
James D. Godkin Jules J. E. Doré

The transforming growth factor βs (TGF-β) belong a family of structurally related, dimeric, disulfide-linked polypeptides that includes five TGF-β isoforms, activins, inhibins, Müllerian inhibiting substance, bone morphogenic proteins, and products of the Xenopus Vg1 and Drosophila decapentaplegic (dpp) genes (reviewed in Rizzino, 1988; Massagué, 1990; Roberts and Sporn, 1990). In mammals, thre...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2012
Tjitske A Oenema Marieke Smit Lyanne Smedinga Kurt Racké Andrew J Halayko Herman Meurs Reinoud Gosens

Acetylcholine (ACh) is the primary parasympathetic neurotransmitter in the airways. Recently, it was established that ACh, via muscarinic receptors, regulates airway remodeling in animal models of asthma and chronic obstructive pulmonary disease (COPD). The mechanisms involved are not well understood. Here, we investigated the functional interaction between muscarinic receptor stimulation and t...

2014
Mayu Arase Kana Horiguchi Shogo Ehata Masato Morikawa Shuichi Tsutsumi Hiroyuki Aburatani Kohei Miyazono Daizo Koinuma

Transforming growth factor (TGF)-β exhibits both pro-apoptotic and anti-apoptotic effects on epithelial cells in a context-dependent manner. The anti-apoptotic function of TGF-β is mediated by several downstream regulatory mechanisms, and has been implicated in the tumor-progressive phenotype of breast cancer cells. We conducted RNA sequencing of mouse mammary gland epithelial (NMuMG) cells and...

2014
Gabriella Pál Gábor Lovas Arpád Dobolyi

Transforming growth factor-βs (TGF-βs) regulate cellular proliferation, differentiation, and survival. TGF-βs bind to type I (TGF-βRI) and II receptors (TGF-βRII), which are transmembrane kinase receptors, and an accessory type III receptor (TGF-βRIII). TGF-β may utilize another type I receptor, activin-like kinase receptor (Alk1). TGF-β is neuroprotective in the middle cerebral artery occlusio...

Journal: :Cells 2023

Chronic wounds affect more than 2% of the population worldwide, with a significant burden on affected individuals, healthcare systems, and societies. A key regulator entire wound healing cascade is transforming growth factor beta (TGF-β), which regulates not only inflammation extracellular matrix formation but also revascularization. This present work aimed at characterizing tissues obtained fr...

2015
Jeong-Hwan Yoon Katsuko Sudo Masahiko Kuroda Mitsuyasu Kato In-Kyu Lee Jin Soo Han Susumu Nakae Takeshi Imamura Juryun Kim Ji Hyeon Ju Dae-Kee Kim Koichi Matsuzaki Michael Weinstein Isao Matsumoto Takayuki Sumida Mizuko Mamura

Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) are the pivotal cytokines to induce IL-17-producing CD4(+) T helper cells (TH17); yet their signalling network remains largely unknown. Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3 oppositely modify STAT3-induced transcription of IL-17A and retinoic acid receptor-related orphan nuc...

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