troencephalography (EEG) in rats. First, the stimulatory action by caffeine i.y. administratlon at a level higher than 5"mollkg (O.970 mg!kg) b.w. was shown by means of brain wave analysis, and this level was suggested as the minim"m dese of caffeine as a stimulant. Next, the stimulatory effects of caffeine were inhibited by an i.v. administration of theanine at a level higher than 5pmol!kg (O....

melatonin, a pineal gland secreted hormone has different effects on mammalian physiology. recently, specific receptors of melatonine have been found in the central nervous system and spinal cord of rabbits. l - theanine is a unique amino acid in the tea plant ( camellia sinensis ). the effects of this amino acid is based on increasing gaba and dopamine levels in the brain and has a weak effect ...

Recent neuropharmacological research has suggested that certain constituents of tea may have modulatory effects on brain state. The bulk of this research has focused on either L-theanine or caffeine ingested alone (mostly the latter) and has been limited to behavioral testing, subjective rating, or neurophysiological assessments during resting. Here, we investigated the effects of both L-theani...

The present work was aimed to study the protective effect of l-theanine on chronic restraint stress (CRS)-induced cognitive impairments in mice. The stress was produced by restraining the animals in well-ventilated polypropylene tubes (3.2 cm in diameter ×10.5 cm in length) for 8h once daily for 21 consecutive days. L-theanine (2 and 4 mg/kg) was administered 30 min before the animals subjected...

Tea has been consumed for thousands of years and is an integral part of people’s daily routine, as an everyday drink and a therapeutic aid for health promotion. Consumption of tea has been linked to a sense of relaxation commonly associated with the content of the non-proteinogenic amino acid theanine, which is found within the tea leaves. The aim of this review article is to outline the curren...

INTRODUCTION The purpose of this study was to investigate the efficacy and safety of L-theanine as an aid to the improvement of objectively measured sleep quality in a population of 98 male children formally diagnosed with attention-deficit/hyperactivity disorder (ADHD). METHODS A randomized, double-blind, placebo-controlled trial was conducted involving boys, ages 8-12 years, who had been pr...

l-Theanine is a nonprotein amino acid with much beneficial efficacy. We found that intraperitoneal treatment of the mice l-theanine (100 mg/kg/day) enhanced adaptive thermogenesis and induced browning inguinal white adipose tissue (iWAT) elevated expression Prdm16, Ucp1, other thermogenic genes. Meanwhile, administration increased energy expenditure. In vitro studies indicated development brown...

Tea (Camellia sinensis) is widely considered to promote feelings of calming and soothing. This effect attributed L-theanine (L-?-glutamylethylamide) in tea, a non-protein amino acid mainly derived from tea leaves. As naturally occurring structural analogue glutamate, competes for the receptors with glutamate able pass blood-brain barrier exert its relaxation effect. review focuses on L-theanine...