Patients often respond differently to a treatment because of individual heterogeneity. Failures of clinical trials can be substantially reduced if, prior to an investigational treatment, patients are stratified into responders and nonresponders based on biological or demographic characteristics. These characteristics are captured by a predictive signature. In this paper, we propose a procedure ...

The objective of this article is to provide a qualitative analysis of the practical concerns that people with HIV/AIDS have with regard to their use of complementary therapies. In-depth semistructured interviews were conducted with a diverse range of people with HIV/AIDS (N = 46). An inductive grounded approach was used to collect and analyze the data. There were five central concerns: (a) sele...

Purpose Reflexology is one of the top six complementary therapies used in the UK. Reflexologists claim that massage to specific points of the feet increases blood supply to referred or ‘mapped’ organs in the body. Empirical evidence to validate this claim is scarce. This three-phase study measured changes in cardiovascular parameters in subjects receiving reflexology treatment applied to specif...

results each group comprised 27 students; eventually, 26 in the homeopathic and 21 in the placebo group were followed up. there was no significant difference between the groups for either pain intensity (adjusted difference: -0.44; 95% ci: -1.43 to 0.54) or any other outcomes. compared with the baseline scores, statistically significant improvements were observed in pain intensity (p = 0.021) a...

a neurological disorder is any disorder of the nervous system is usually due to cell loss. the ultimate goal of cns therapy is to replace lost cells and tissue. there is no neuroprotective, pharmacological and effective treatment available that restores the injury-induced loss of function. recent studies suggest that identification of adult neural stem/progenitor cells indwelling in the neuroge...

dentin hypersensitivity (dh) is a relatively common painful condition among dental problems. although many studies have been performed regarding the diagnosis and treatment of dh, dental practitioners are still confused about the definite diagnosis and treatment.the use of lasers as a treatment for dentin hypersensitivity was first introduced in 1985. laser treatment in dentin hypersensitivity ...

purpose: multiple sclerosis is a progressive neurological disease and a cause of many disabilities in individuals. set of symptoms and the chronic nature of this disease, together impair the mental state of the person and cause awidervariety of psychological symptoms worsening the disease. therefor, this study aimed to evaluate the effectiveness of cognitive therapy based on mindfulness psychol...

Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...

background degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. the principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. to briefly review the lines of research and potential candidates for cell based therapies among r...