BACKGROUND Environmental exposure of infants to perchlorate, thiocyanate, nitrate, might interfere with thyroid function. U.S. women with higher background perchlorate exposure have higher thyroid-stimulating hormone (TSH) and lower thyroxine (T4). There are no studies with individual measures of thyroid function and these goitrogens available in infants. OBJECTIVE We examined the association...

MOODY, FRANK G. Oxygen consumphn during thiocyanate irhibition of gastric acid secretion in dog. Am. J, Physiol. 2 15( 1) : 127-131. 1968.-The relationship between oxygen c&sumption, blood flow, and acid secretion was studied in exteriorized gastric se gments of the dog during histamine and thiocyanate administration. Acid secretion and oxygen consumption demonstrated a highly significant linea...

In a previous paper (1) we reported data, based upon the use of radiosulfur, showing that in the rat the affinity of the whole thyroid for thiocyanate ion is slight but is significantly greater than in other tissues. Baumann and Metzger (2), using different analytical procedures, reported a similar observation. The uptake of thiocyanate ion by the thyroid is of especial interest because of the ...

–Allosteric regulators of á-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors include 2,3-benzodiazepines such as GYKI 52466 and GYKI 53655 and the chaotropic anion thiocyanate that inhibit, and benzothiadiazines such as cyclothiazide that potentiate AMPA receptor currents. Here we sought to determine whether the allosteric regulators modulate AMPA receptors at a common or distin...

I . In the aetiopathogenesis, in Nigerians, of a degenerative neuropathy known as tropical ataxic neuropathy, chronic cyanide intoxication is believed to be the most important factor. The source of the cyanide is cassava (Manihot) and in Nigerian patients, plasma concentration of thiocyanate, a major detoxication product of cyanide, is high. 2. Since there is considerable doubt as to whether cy...

A flow-through spectrophotometric bulk optode for the flow-injection determination of thiocyanate is described. As active constituents, the optode incorporates the lipophilized pH indicator 5-octadecanoyloxy-2-(4-nitrophenylazo)phenol and methyltridodecyl ammonium chloride, dissolved in a plasticized poly(vinyl)chloride membrane entrapped in a cellulose support. The optode is applied, in conjun...

The Colorado River is contaminated with low levels of perchlorate. Perchlorate has the potential to disrupt thyroid function by inhibiting the uptake of iodide. Brassica are rich sources of thiocyanate and nitrate, also inhibitors of iodide uptake. This study was conducted to estimate potential human exposure to perchlorate, thiocyanate, and nitrate from Brassica sp. irrigated with Colorado Riv...

Previous studies (Jakobi, Jakobi, and Cavalcanti, 1961) have suggested that the concentration of thiocyanate in the saliva of patients suffering from oesophageal or gastric cancer is unusually low compared with that in normal subjects or patients with peptic ulcer. If this were confirmed the measurement of salivary thiocyanates might provide a screening test for gastric cancer. Salivary thiocya...

BACKGROUND Perchlorate and thiocyanate interfere with iodide uptake at the sodium-iodide symporter and are potential disruptors of thyroid hormone synthesis. Perchlorate is a common contaminant of water, food, and human milk. Although it is known that iodide undergoes significant diurnal variations in serum and urinary excretion, less is known about diurnal variations of milk iodide levels. O...