OBJECTIVE To determine whether heritable thrombophilia and hypofibrinolysis were risk factors for retinal vein occlusion. DESIGN Measures of thrombophilia (increased likelihood of thrombus formation) included anticardiolipin antibodies (IgG and IgM), the lupus anticoagulant (including dilute Russell viper venom clotting time), antigenic proteins C and S, and homocysteine. Polymerase chain rea...

Background: Recurrent pregnancy loss (RPL) is a common problem among couples, and acquired thrombophilia is the well-known etiology of RPL. The aim of this study was to establish the association between inherited thrombophilic gene polymorphisms and RPL. Methods: This case-control study was conducted on 50 women with unexplained RPL and 50 parous women with no history of miscarriage (age range...

Inherited thrombophilia is thought to increase the risk of pregnancy related venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE). Pregnancy is a hypercoagulable state due to the increased concentration of coagulation factors, decreased natural anticoagulants and fibrinolytic activity1. The pregnant woman is therefore at increased risk for VTE and this ...

OBJECTIVE To investigate the impact of inherited thrombophilic factors on the gestational outcome of unselected pregnant women. METHOD A total of 392 women with spontaneous pregnancy were investigated for Factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations. Adverse pregnancy outcomes were recorded. RESULTS Thrombophilic genotypes were significantly higher in women with placental...

The role of heritable thrombophilic risk factors in the pathogenesis of the Perthes' disease is controversial. The clinical and radiological findings of Perthes' disease may be indistinguishable from those of Gaucher's disease, and the most common Jewish N370S Gaucher mutation is threefold greater in patients with Perthes' disease. Familial osteonecrosis of the femoral head is associated with v...