Thromboprophylaxis is underused in patients with cancer, despite the fact that malignancy is a serious risk factor for venous thromboembolism in this population. Major medical guidelines, including those published recently by the American College of Chest Physicians, the American Society of Clinical Oncology, and the National Comprehensive Cancer Network, recommend routine thromboprophylaxis fo...

The efficacy and safety of the new oral anticoagulants (NOAC) and the benefits of extended duration thromboprophylaxis following hip and knee replacements remain uncertain. This observational study describes the relations between thromboprophylaxis policies following hip and knee replacements across England's NHS and patient outcomes between January 2008 and December 2011. From the national adm...

The administration of heparin during operation has been reported to enhance the efficacy of thromboprophylaxis in patients undergoing total hip replacement. We have performed a small pilot study in which intraoperative doses of heparin were given in addition to the usual postoperative thromboprophylaxis with enoxaparin in 32 patients undergoing total knee replacement. The primary endpoint was d...

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), is a common and severe complication of critical illness. Although well documented in the general population, the prevalence of PE is less known in the ICU, where it is more difficult to diagnose and to treat. Critically ill patients are at high risk of VTE because they combine both general risk fac...

Venous thromboembolism (VTE), comprising pulmonary embolism (PE) and deep vein thrombosis (DVT), is a common and potentially fatal disease. Since it is frequently asymptomatic, prevention is the most effective means to reduce morbidity and mortality. Although thromboprophylaxis is recommended in patients undergoing general and orthopaedic surgery and those with trauma, acute myocardial infarcti...

BACKGROUND It is well known that a significant proportion of hospitalized medical and surgical patients with risk factors for deep vein thrombosis (DVT) are not receiving thromboprophylaxis. We designed this study to evaluate the proportion of at-risk patients and the proportion of those receiving recommended prophylaxis. METHODS We conducted a multicentric cross-sectional survey that include...

Thromboprophylaxis remains a controversial subject. A vast amount of epidemiological and trial data about venous thromboembolism has been published over the past 40 years. These data have been distilled and synthesised into guidelines designed to help the practitioner translate this extensive research into 'evidence-based' advice. Guidelines should, in theory, benefit patient care by ensuring t...

Objectives. To compare the effectiveness of postcesarean thromboprophylaxis with two different regimens of bemiparin. Material and Methods. The study included 646 women with cesarean delivery in our hospital within a 1-year period, randomly assigned to one of two groups for prophylaxis with 3500 IU bemiparin once daily for 5 days or 3500 IU bemiparin once daily for 10 days. Results. There was o...

Comment on: Pharmacologic Thromboprophylaxis and Thrombosis in Hospitalized Patients with COVID-19: A Pooled AnalysisThromb Haemost 2021; 121(01): 076-085DOI: 10.1055/s-0040-1721664

BACKGROUND This guideline addressed VTE prevention in hospitalized medical patients, outpatients with cancer, the chronically immobilized, long-distance travelers, and those with asymptomatic thrombophilia. METHODS This guideline follows methods described in Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis Guidelines: Antithrombotic Therapy and Prevention...