BACKGROUND AND AIMS Thrombosis of the small intrahepatic veins has been suggested to trigger liver tissue remodelling. We evaluated the prevalence of multiple thrombotic risk factors and their association with the extent of fibrosis in chronic viral hepatitis. METHODS Ninety consecutive patients with chronic hepatitis B or C without malignancy, a history of venous thrombosis, or antiviral/imm...

Background and aims: Thrombosis of the small intrahepatic veins has been suggested to trigger liver tissue remodelling. We evaluated the prevalence of multiple thrombotic risk factors and their association with the extent of fibrosis in chronic viral hepatitis. Methods: Ninety consecutive patients with chronic hepatitis B or C without malignancy, a history of venous thrombosis, or antiviral/imm...

We investigated the cardiovascular thrombotic risk after surgical castration (SC) versus gonadotropin-releasing hormone agonists (GnRHa) in Chinese men with prostate cancer. All Chinese prostate cancer patients who were treated with SC or GnRHa from year 2000 to 2009 were reviewed and compared. The primary outcome was any new-onset of cardiovascular thrombotic events after SC or GnRHa, which wa...

Heparin cofactor II (HCII) is a specific inhibitor of thrombin in the presence of heparin or dermatan sulphate. Although there have been reports on families in which a heterozygous HCII deficiency is associated with thromboembolic events, several epidemiological studies revealed that heterozygous HCII deficiency is as prevalent among healthy subjects as it is among patients with deep venous thr...

tlte usual manifestation of acute promyelocyte leukemia is hemorrliagic tendency hut thrombotic manifestations may dominate the clinical picture. we report a patient with promyelocyte leukemia which presented as thrombotic cerebrovascular accident and responded to all-transretionic acid and chemotherapy.

Traditionally, perioperative bleeding complications were a major concern during orthotopic liver transplantation, but a tremendous decline in transfusion requirements has been reported over the last decade. In recent years, there has been an increasing awareness towards perioperative thrombotic complications, including liver vessel thrombosis, and systemic venous and arterial thromboembolic eve...

The patient, a 68-year old female with type 1 VWD (VWF antigen [VWF:Ag] 16 IU/dL, ristocetin cofactor [VWF:RCo] 20 IU/dL, coagulant factor VIII [FVIII:C] 15 IU/dL]) responsive to desmopressin (DDAVP) and heterozygous for factor V Leiden and prothrombin G20210A mutations, experienced a pulmonary embolism during a hip replacement operation. She had been given 3000 FVIII IU of FVIII/VWF concentrat...

BACKGROUND AND OBJECTIVES The prothrombin G20210A mutation and factor V Leiden have been found to be associated with an increased risk of venous thrombosis, but the reported prevalences of the prothrombin gene variant both in the normal population and in patients with deep venous thrombosis (DVT) vary greatly in the literature. Moreover, the influence of oral contraceptives (OC) on thrombotic e...