BACKGROUND Flow-induced regulation of endothelial NO synthase (eNOS) depends on integrin signaling and tyrosine kinase activation. Integrins cluster in focal adhesion complexes, where the extracellular matrix is connected to the cytoskeleton and where focal adhesion kinase (FAK) is located. FAK plays a central role in integrin signaling and Src activation. Accordingly, we hypothesized that FAK ...

Introduction Pass-band bSSFP is a promising tool for high-resolution fMRI, but its signal sources have been unclear especially at high field. The bSSFP signals are summation of free induction decay (FID) component and echo components from multiple RF pathways. Multiple TR and TE experiments have been used in previous studies to understand contributions of FID and echo components to the signals ...

BACKGROUND Fever of intermediate duration (FID), characterized by a febrile syndrome lasting from 7 to 28 days, is a frequent condition in clinical practice, but its epidemiological and etiologic features are not well described. Murine typhus (MT) is a worldwide illness; nevertheless, to our knowledge, no studies describing its epidemiological and clinical characteristics have been performed in...

Our previous studies demonstrated that, in gracilis muscle arterioles of male mice deficient in the gene for endothelial nitric oxide synthase (eNOS), flow-induced dilation (FID) is mediated by endothelial PGs. Thus the present study aimed to identify the specific isoform of cyclooxygenase (COX) responsible for the compensatory mediation of FID in arterioles of eNOS-knockout (KO) mice. Experime...

Recently, various researches on medical image generation have been suggested, and it becomes crucial to accurately evaluate the quality diversity of generated images. For this purpose, expert’s visual turing test, feature distribution visualization, quantitative evaluation through IS FID are evaluated. However, there few methods for quantitatively evaluating images in terms fidelity diversity. ...

ABSTRACT: Acrylamide is a chemical compound that has been widely used since the last century for various applications. It is also formed from carbohydrate and amino acid containing foods by application of heat particularly in fried potato products, coffee and bread. Since bread is one of the primary foods of Iranian people, the determination of acrylamide content in bread might be considered im...

Introduction: MR spectroscopy can be used to identify various metabolites and their quantities in vivo and provide biochemical information that can be correlated with disease. For example, MR spectroscopy of the brain can show levels of creatinine (Cr), choline (Cho), and N-acetyl aspartate (NAA), which are correlated with the presence or absence of tumor. One of the major drawbacks in MR spect...

In North America and Europe, deer (Cervidae)–vehicle collisions (DVCs) are common and result not only in injury and death to the animals involved, but also human injury and property damage. Given that most DVCs occur during crepuscular periods, we questioned whether the perceived threat to deer posed by vehicle approach could be enhanced. We hypothesized that a vehicle-based lighting system tha...

We present FiD (Fragment iDentificator), a software tool for the structural identification of product ions produced with tandem mass spectrometric measurement of low molecular weight organic compounds. Tandem mass spectrometry (MS/MS) has proven to be an indispensable tool in modern, cell-wide metabolomics and fluxomics studies. In such studies, the structural information of the MS(n) product i...

Escape enables prey to avoid an approaching predator. The escape decision-making process has traditionally been interpreted using theoretical models that consider ultimate explanations based on the cost/benefit paradigm. Ultimate approaches, however, suffer from inseparable extra-assumptions due to an inability to accurately parameterize the model's variables and their interactive relationships...