Introduction It is now almost100 years ago that the first victim with severe dementia associated with neuronal cell death was studied by Alois Alzheimer. By that time such cases were very unusual and Alois Alzheimer had the chance to see only two patients throughout his life. Now Alzheimer’s disease (AD) is a very frequent disorder, which affects millions worldwide. Only within Germany, about 1...

Abu Ali Hossein Ebn Abdullah Ben Ali Ben Sinna entitled as Shayhk-o-Rayeis in the East and well known in the west by the name of Avicenna was born in a place called Afsharneh near the city of Bokhara in 980 AD but resided in the city of Balkh. He was five years old when his father took him to the city of Bokhara to study Holy Quran where his extraordinary memory became apparent and he memorized...

Abu Ali Hossein Ebn Abdullah Ben Ali Ben Sinna entitled as Shayhk-o-Rayeis in the East and well known in the west by the name of Avicenna was born in a place called Afsharneh near the city of Bokhara in 980 AD but resided in the city of Balkh. He was five years old when his father took him to the city of Bokhara to study Holy Quran where his extraordinary memory became apparent and he memorized...

Life is the most valuable asset that a person has. Throughout time allotted to him, he seeks meaning of his existence, makes plans, strives implement them, creates and creates. And main task preserve this life, because it priceless. Scientists have long established direct link between quality drinking water life expectancy. The rapid growth planets population in combination with increasing cons...

The polar flagellum of Vibrio alginolyticus is rotated by the sodium motor. The stator unit of the sodium motor consists of four different proteins: PomA, PomB, MotX and MotY. MotX and MotY, which are unique components of the sodium motor, form the T-ring structure attached to the LP ring in the periplasmic space. MotY has a putative peptidoglycan-binding motif in its C-terminal region and MotX...

The recombinant expression of soluble proteins in Escherichia coli continues to be a major bottleneck in structural genomics. The establishment of reliable protocols for the performance of small-scale expression and solubility testing is an essential component of structural genomic pipelines. The SSGCID Protein Production Group at the University of Washington (UW-PPG) has developed a high-throu...

BACKGROUND Functional Genomics, the systematic characterisation of the functions of an organism's genes, includes the study of the gene products, the proteins. Such studies require methods to express and purify these proteins in a parallel, time and cost effective manner. RESULTS We developed a method for parallel expression and purification of recombinant proteins with a hexahistidine tag (H...

A practically simple top-down process for the exfoliation of graphene (GN) and few-layer graphene (FLG) from graphite is described. We have discovered that a biocompatible amphiphilic pyrene-based hexahistidine peptide is able to exfoliate, functionalize, and dissolve few layer graphene flakes in pure water under exceptionally mild, sustainable and virtually innocuous low intensity cavitation c...