A simultaneous pancreas-kidney transplant recipient developed serum sickness manifesting with severe upper limb allodynia, arthralgia and myalgia 17 days following rabbit anti-thymocyte globulin (rATG) infusion for biopsy-proven vascular rejection. Rapid resolution of symptoms followed treatment with high-dose glucocorticoids. rATG is increasingly favoured over equine ATG in solid-organ transpl...

kaposi᾽s sarcoma (ks) can develop in 0.06% to 4.1% of kidney transplant recipients. here we describe a case of 50-year-old man who developed ks a few months after kidney transplantation . after transplantation, he had delayed graft function and was managed by anti-thymocyte globulin (atg) for five days. at the discharge, his immunosuppressive therapy was prednisolone 20 mg/day, ttacrolimus (ppr...

We have previously shown that laminin-5 is expressed in the human thymic medulla, in which mature thymocytes are located. We now report that laminin-5 promotes migration of mature medullary thymocytes, whereas it has no effect on cortical immature thymocytes. Migration was inhibited by blocking mAbs directed against laminin-5 integrin receptors and by inhibitors of metalloproteinases. Interacti...

BACKGROUND Despite significant nephrotoxicity, calcineurin inhibitors (CNIs) remain the cornerstone of immunosuppression in solid organ transplantation. We, along with others, have reported tolerogenic properties of anti-thymocyte globulin (ATG, Thymoglobulin®), evinced by its ability both to spare Tregs from depletion in vivo and, when administered at low, non-depleting doses, to expand Tregs ...

SIR, The detailed study of aggressive immunosuppressive treatment of scleroderma by Stratton et al. [1] is of great interest. Certainly novel approaches are justified in a rheumatic disease which has proved resistant to all forms of treatment. Indeed my colleagues and I instituted a similar trial of anti-thymocyte in combination with other immunosuppressive drugs which was reported in a confere...

An antigen-specific suppressive T-cell factor was extracted from physically disrupted thymocytes and spleen cells of mice that had been immunized with soluble protein antigens. The factor, when inoculated into syngeneic normal mice, could induce a significant suppression of IgG antibody response against a hapten coupled to the carrier protein by which the donor of the suppressor factor was immu...