The effects of some exogenous peripheral hormones (thyroxine, corticosterone, epinephrine, norepinephrine and insulin) on thyroid activity were investigated in juvenile female soft-shelled turtles, Lissemys punctata punctata. Each hormone was injected in three different doses (25 microg, 50 microg or 100 microg each per 100 g body weight, once daily at 9 AM) for 10 consecutive days. Thyroid act...

Since the FDA approved sorafenib use for thyroid cancer, administration of this medicine to thyroid-cancer patients had steadily increased. However, an appropriate starting dose for this treatment has not been established, which is problematic because the sorafenib discontinuation rate due to toxicity is higher among thyroid cancer patients than among patients with other solid tumors. We recent...

objective(s): the aim of this study was to determine whether high-dose radioactive iodine (na131i) outpatient treatment of patients with thyroid carcinoma is a pragmatically safe approach, particularly for the safety of caregivers. methods: a total of 79 patients completed the radiation-safety questionnaires prior to receiving high-dose radioactive iodine treatment. the questionnaire studied th...

introduction: thyroid hormone is important for the growth, development and metabolism of the body. a new amount of data show that thyroid hormone influences on pituitary-testis axis. so in this study we investigated the effects of hypothyroidism induction by propiltiouracil (ptu) on serum levels of thyroid hormone, testosterone hormone, luteinizing hormone, follicle stimulating hormone, body an...

The 1986 accident at the Chernobyl nuclear power plant remains the most serious nuclear accident in history, and excess thyroid cancers, particularly among those exposed to releases of iodine-131 remain the best-documented sequelae. Failure to take dose-measurement error into account can lead to bias in assessments of dose-response slope. Although risks in the Ukrainian-US thyroid screening stu...

UNLABELLED We evaluated the effects on the absorbed dose to thyroid follicular cells of self-absorption of (131)I radiation (specifically, beta-rays) in the follicular colloid. METHODS Thyroid follicles were modeled as colloid-filled spheres, containing a uniform concentration of (131)I and surrounded by a concentric monolayer of cells. Assuming close packing of identical follicles, we used M...

Background In radiotherapy, especially when treating children, minimising exposure of healthy tissue can prevent the development adverse outcomes, including second cancers. this study we propose a validated Monte Carlo framework to evaluate complete patient during paediatric brain cancer treatment. Materials and methods Organ doses were calculated for treatment diffuse midline glioma (50.4 Gy w...

The purpose of the present study was to determine the risk factors for developing thyroid disorders based on a dose-volume histograms (DVHs) analysis. Data from a total of 116 consecutive patients undergoing 3D conformal radiation therapy for head and neck cancers was retrospectively evaluated. Radiation therapy was performed between April 2007 and December 2010. There were 108 males and 8 fema...

Background: Practice of interventional cardiology procedures such as Coronary angiography (CA) and percutaneous transluminal coronary angioplasty (PTCA) has largely increased in recent years and is now changing to a matter of routine in many hospitals. The purpose of this study was to measure skin and organ doses in patients undergoing CA and PTCA and to find a probable relation with c...